9 years) to determine driving reaction time (DRT) before and afte

9 years) to determine driving reaction time (DRT) before and after surgery in patients with lumbar disc herniation. Of the patients 23 had left-side radiculopathy and 23 right-side radiculopathy. Driving reaction time as well as back and leg pain were evaluated preoperatively, on the day of discharge from hospital and at the 5-week follow-up examination (FU). 31 healthy subjects were tested as controls.

Significant improvement in DRT was seen for both patient samples (p < 0.05). For patients with a right-side radiculopathy preoperative DRT was 664 ms (median, IQR: 241), which was reduced to 605 ms (median, IQR: 189) immediately postoperatively and to 593 ms (median, IQR: 115) at FU. For

patients with a left-side radiculopathy DRT was 675 ms (median, IQR: 247) preoperatively, 638 ms (median, IQR: 242) postoperatively and 619 ms (median, IQR: 162) at FU. Pain was moderately

correlated to DRT. Control subjects had a driving reaction time GDC 941 of 487 (median, IQR: 116), which differed significantly from patients at all three testing times selleck screening library (p < 0.001).

Our data indicate a positive effect of the surgery on driving ability. Therefore, we would suggest that for both patient samples it is safe to continue driving after hospital discharge. However, patients have to be informed about increased DRT caused by radiculopathy already before surgery.”
“SETTING: The National Tuberculosis Programme (NTP) of Benin, West Africa.

OBJECTIVE: To verify the accuracy of the data published by the NTP in terms of notified cases and treatment results.

DESIGN: Purposeful selection of nine basic management units (BMUs) that had declared zero tuberculosis (TB) patients lost to follow-up in the first three quarters of 2006. Retrospective onsite survey by independent teams based on the documents kept at the BMUs, on the data transmitted to and compiled at the central level and on home interviews with patients who had been

declared treatment successes.

RESULTS: Of the 446 cases evaluated, there PXD101 molecular weight was excellent agreement between the TB register and the TB treatment card, between the TB register and the quarterly reports and between the TB register and the laboratory register. Home interviews with 32 patients all confirmed the information contained in the treatment cards and the TB register.

CONCLUSION: The results published by the NTP of Benin are remarkably reliable.”
“Prospective observational cohort study.

Comparison of clinical and radiological outcomes of single-level open versus minimally invasive (MIS) transforaminal lumbar interbody fusion (TLIF) at 6 months and 2-year follow-up.

There is recognition that more data are required to ascertain the benefits and risks of MIS vis-a-vis open TLIF. This study aims to report on one of the largest currently available series comparing the clinical and radiological outcomes of the two procedures with a minimum follow-up of 2 years.

Aspergillosis affecting the musculoskeletal system is rare We de

Aspergillosis affecting the musculoskeletal system is rare. We describe here a case of articular aspergillosis in a febrile neutropenic patient successfully treated with voriconazole and caspofungin, and briefly review the 10 cases of articular aspergillosis that have previously been described in the literature. (C) 2009 International

Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“Objective. We studied the correlation between the clinical and histopathologic diagnoses of oral lichen planus (OLP) based on the modified World Health Organization (WHO) diagnostic criteria (2003).

Study design. First, 4 oral pathologists and 4 clinicians reviewed and categorized 62 microscopic slides and clinical photographs based on WHO 1978 criteria, and then based Histone Methyltransf inhibitor on modified WHO definition. The number of photographs and microscopic slides in which all clinicians and all pathologists agreed were calculated and compared.

Results. Based on 1978 criteria, in 68% of cases in which all clinicians agreed about the diagnosis of OLP, all pathologists PF 00299804 agreed about the diagnosis of OLP. Conversely, in 79% of cases in

which all pathologists agreed on the diagnosis of OLP, all clinicians agreed on the diagnosis of OLP. Based on modified criteria, in 93.87% of cases in which all clinicians agreed on the diagnosis of OLP, all pathologists agreed on the diagnosis of OLP. Similarly, in 95.83% of the cases in which all pathologists agreed about the diagnosis of OLP, all clinicians agreed about the diagnosis of OLP.

Conclusion. Results show higher clinicopathologic correlation in the diagnosis of OLP based on the modified criteria of OLP

compared with the 1978 criteria. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: 796-800)”
“Background: Increased www.selleckchem.com/products/BafilomycinA1.html serum leptin concentration has been linked to increased ventilation in patients with mild heart failure (HF). However, in animal models the absence of leptin has also been associated with increased ventilation. This study evaluated the relationship of circulating leptin concentration with exercise ventilation in HF patients.

Methods and Results: Fifty-eight consecutive ambulatory HF patients were stratified by quintiles of leptin concentration, with a lowest quintile of mean leptin concentration of 1.8 +/- 8.9 ng/mL and a highest of 33.3 +/- 30.3 ng/mL. Peak exercise ventilatory efficiency (VE/VCO2) was significantly elevated in the lowest (46 +/- 6 vs 34 +/- 4; P < .01) as well as in the highest (38 +/- 8 vs 34 +/- 4; P < .05) leptin concentration quintiles compared with the reference middle quintile. Multiple regression analysis adjusted for confounders such as age, sex, and body mass index showed leptin concentration to be independently inversely correlated to VE/VCO2 in the low-to-normal quintiles (beta = -0.64; P < .01), positively in the normal-to-high quintiles (beta = 0.52; P = .

All the cases were evaluated using complete audiological test bat

All the cases were evaluated using complete audiological test battery consisting of pure tone audiometry (PTA), impedance audiometry, acoustic reflexes, otoacoustic emissions (OAE), and brain stem evoked response audiometry (BERA). The instrument used was GSI Audera. BERA with both condensation and rarefaction polarity was performed in cases with absent wave V even at highest intensity levels. The criteria used for diagnosis of ANSD was normal or near normal cochlear hair cells (sensory) function (preservation of otoacoustic emissions and/or cochlear microphonics) and absent or abnormal auditory nerve function (absent or severely abnormal auditory brainstem JAK inhibitor potentials). A repeat test battery

was performed after 3 months on the diagnosed cases of auditory neuropathy. Based on their behavioural findings the appropriate management

programme was formulated.

Results: A total of 487 paediatric cases were referred for hearing evaluation. 183 (37.6%) cases showed absent BERA and 26(5.3%) cases fulfilled the diagnostic criteria for ANSD. Repeat examination after 3 months revealed presence of OAE’s in 57.6% (15/26) cases while cochlear microphonics were present in all the 26 cases.

Conclusion: The prevalence of ANSD in our study is 5.3% and in children diagnosed with severe to profound hearing loss is 14%. Presence of cochlear microphonics with absent BERA seems to be reliable criteria for diagnosing ANSD. (c) 2012 Elsevier Ireland Ltd. All rights reserved.”
“The reaction of isocyanates and isothiocyanates with long-chain alcohols, e. g. SNX-5422 purchase n-hexanol, n-heptanol and n-octanol, exclusively gave N-aryl-O-alkyl carbamates, while N-aryl-O-alkyl carbamates were signaling pathway formed along with symmetrical 1,3-disubstituted ureas and thioureas when the same reactions were carried out with small-chain alcohols at room temperature without using any solvent.”

To evaluate whether the addition of BCS (balloon catheter sinuplasty) would improve the treatment outcome in children with chronic rhinosinusitis (CRS) compared to FESS (functional endoscopic sinus surgery).

Study design: Two-group, retrospective cohort with blinded chart review comparison.

Setting: Children’s Hospital of Michigan, Detroit, MI.

Subjects and methods: Chart review of 15 pediatric patients who underwent BCS with ethmoidectomy and 16 who underwent FESS from 2008 to 2011 for treatment of CRS in a tertiary care, university affiliated, pediatric institution. Pre-operative CT-scans as well as pre and post-operative sinus symptoms and medications were compared. Post-surgical outcome was examined using chi square analysis.

Results: Mean age of children at the time of the procedure was 9.3 (SD = 4.19; range = 3-17). Both groups had similar pre-surgical Lund-Mackay CT CRS scores (FESS: mean = 9.33 and t = 0.67; balloon: mean = 10.58, t = 0.68, and p = 0.51).

Our data show that the nature and extent of molecular motion vari

Our data show that the nature and extent of molecular motion varies considerably with moisture and temperature, and that the hydrated conditions used for accelerated aging experiments and ultra-dry conditions sometimes recommended for seed storage

give greater molecular mobility than more standard seed storage practices. We believe characterization of molecular mobility is critical for evaluating how dry seeds respond to the environment and persist through time.”
“Poor bioavailability of topically instilled drug is the major concern in the field of ocular drug delivery. Efflux transporters, static and dynamic ocular barriers often possess rate limiting factors for ocular drug therapy. MAPK inhibitor Different formulation strategies like suspension, ointment, gels, nanoparticles, implants, dendrimers and liposomes have been employed in order to improve GM6001 order drug permeation and retention by evading rate limiting factors at the site of absorption. Chemical modification such as prodrug targeting various nutrient transporters (amino acids, peptide and vitamin) has evolved a great deal of interest to improve ocular drug delivery. In this review, we have discussed various prodrug strategies which have been widely applied for enhancing therapeutic efficacy of ophthalmic drugs. The purpose of this review

is to provide an update on the utilization of prodrug concept in ocular drug delivery. In addition, this review will highlight ongoing academic and industrial research and development in terms of ocular selleck products prodrug design and delivery.”
“The purpose of this study was to review and evaluate systematically the scientific evidence on the relationship between systemic lupus erythematosus (SLE), human papillomavirus (HPV) infection, pre-cancerous cervical abnormalities, and cervical cancer. Establishing strict inclusion and exclusion criteria, we performed an extensive search for studies in MEDLINE and BIREME databases to assess the studies that evaluated

the frequency of HPV infection, pre-cancerous cervical abnormalities, and cervical cancer in women with SLE. Secondary references were additionally obtained from the included articles. Thirty-three articles met the criteria previously established. Fifteen out of 18 studies that performed cytological analysis showed a higher frequency of squamous intraepithelial lesions in SLE patients compared with normal women. Moreover, three studies found a higher frequency of high-grade squamous intraepithelial lesions. Additionally, it was observed that women with SLE had a higher frequency of HPV infection, confirmed by molecular biology techniques. Curiously, despite the above findings, no increased frequency of cervical cancer was observed in the majority of the studies which addressed this issue.

A total of 17 subjects were assessed clinically and had blood sam

A total of 17 subjects were assessed clinically and had blood samples taken for DNA extraction. Multipoint parametric linkage analysis was performed to identify the possible chromosomal location responsible for HGF in this family.

Results Presence of severe HGF associated with tooth impaction was confirmed for seven members of this three-generation family. Linkage analysis revealed that loci on chromosomes 7, 10, 13, 15, 16, 17, 19 and 20 were linked to this trait. Previously found mutations in the SOS1 and GINGF loci

were therefore excluded by this analysis.

Conclusions This study brings further evidence for genetic FRAX597 heterogeneity of HGF and points towards the existence of different, not-yet-identified genes linked to this condition. Oral Diseases (2013) 19, 100-105″
“Background: The translation of novel genomic technologies from bench to bedside enjoins the comprehensive consideration of the perspectives of all stakeholders who stand to influence, or be influenced by, the translational course. Non-invasive prenatal aneuploidy testing that utilizes cell-free fetal DNA (cffDNA) circulating in maternal blood is one example of an innovative technology that promises significant benefits for its intended end users; however, it is currently uncertain selleck products whether it will achieve widespread clinical implementation. We conducted qualitative interviews with 18 diverse stakeholders in this

domain, including prospective users of the technology and healthcare personnel, researchers and developers, buy ACY-738 and experts in social, legal, and regulatory aspects of genetic technology, and a pilot survey of 62 obstetric healthcare providers. Analysis

of interview and survey data was combined with a review of the proceedings of a full-day, multidisciplinary conference on the topic and published scientific and ethics literature surrounding this and other relevant technologies.

Discussion: We constructed potential pathways for technological implementation, identified broad stakeholder classes party to these translational processes, and performed a preliminary assessment of the viewpoints and interrelations among these diverse stakeholders. Some of the stakeholders whose priorities are critical to understand and integrate into translation include pregnant women and their families; healthcare providers; scientists, their institutions or companies, and the funding agencies that support them; regulatory and judicial bodies; third-party payers; professional societies; educational systems; disability rights communities; and other representatives from civil society. Stakeholder interviews, survey findings, and conference proceedings add complexity to these envisioned pathways and also demonstrate a paramount need to incorporate an iterative stakeholder analysis early and throughout the translational endeavor.

“Stevens-Johnson syndrome (SJS) and toxic epidermal necros

“Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) are rare but life-threatening severe cutaneous adverse

reactions (SCARs), which are majorly (65-75%) induced by a variety of drugs. SJS/TEN could be CH5183284 recognized as SCARs or drug immune reactions, if the reactions are elicited by drugs. The recent studies suggested that SJS/TEN is a specific immune reaction initiated by the cytotoxic T lymphocytes (CTLs) via human leukocyte antigens (HLAs)-restricted pathway. The patho-mechanism involving HLA-restricted presentation of a drug or its metabolites for T-cell activation is supported by the findings of strong genetic associations with HLA alleles (e.g. HLA-B*15:02 and carbamazepine-SJS/TEN, and HLA-B*58:01 and allopurinol-SJS/TEN). However, the genetic associations of SJS/TEN or drug induced cutaneous immune reactions are complex, which are drug specific and ethnicity specific. The genetic polymorphisms and diversity of HLA alleles may provide different

binding affinities for drug antigens to launch the activation of specific find more CTLs responses, further leading to the unique clinical manifestations in SJS/TEN. Fas-FasL and perforin/granzyme B have been advocated mediating the epidermal necrosis in SJS/TEN. Our recent study showed that granulysin, a cytotoxic protein produced by CTLs or natural killer (NK) cells, is the key mediator for disseminated keratinocyte death in SJS/TEN. From the point of view of a physician, the profounder understanding of the genetic predisposition and patho-mechanism we discover, the better strategies for prevention, clinical management, and therapeutic methods of SJS/TEN we can develop in the near

Selleck AL3818 future. (C) 2012 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.”
“Purpose: We investigated the effects of clinical and laboratory properties at the time of the initial application of patients recently diagnosed and presenting metabolic indicators of diabetic ketoacidosis who were given disease prognoses in years 1 and 2 after discharge.

Materials and methods: A total of 94 patients admitted to Bakirkoy Maternity and Children’s Diseases Training and Research Hospital with diabetic ketoacidosis and recently diagnosed with type 1 diabetes mellitus were investigated. Patient files were examined within 2 years following discharge.

Findings: All 94 study patients (53.2% male and 46.8% female) presented acidosis, ketonuria and hyperglycemia. While a moderate correlation was detected between the prodromal period and HbA(1c) values in year 1, only a slight correlation was seen in HbA(1c) values in year 2. In addition, a slight correlation was observed between the prodromal period and the number of hospitalizations due to diabetic ketoacidosis in the first year. Again, while a moderate correlation was observed between HbA(1c) values and the number of hospitalizations due to diabetic ketoacidosis in year 1, only a slight correlation was seen in year 2.

Results: A total of 4,804 patients with T2DM

(insulin gla

Results: A total of 4,804 patients with T2DM

(insulin glargine: n = 4,172, insulin detemir: n = 632) were included. The average insulin persistence rate over the 1-year follow-up period was 65.0%. A significantly higher persistence rate was associated with older age, initiation with insulin glargine using either disposable pens or vial-and-syringe, and with baseline exenatide or sitagliptin use. Higher insulin treatment persistence was also associated with lower hemoglobin A(1c) (A1C) at follow-up, a greater reduction in A1C from baseline, and lower health care utilization.

Conclusion: In real-world settings, treatment persistence among patients with T2DM initiating basal insulin is influenced by the type of insulin and patient factors. Greater insulin ARN-509 Endocrinology & Hormones inhibitor treatment persistence is linked to improved HIF-1 cancer clinical outcomes and reduced health care utilization.”
“Thiol compounds exert diverse functions in the defense network against oxidative stress in vivo. Above all, the role of glutathione in the enzymatic removal of hydrogen

peroxide and lipid hydroperoxides has been well established. The scavenging of reactive free radicals is one of the many functions. In this study, the reactivities of several thiol compounds toward oxygen- and nitrogen-centered radicals were measured from their reaction with galvinoxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and also from their sparing effects on the decay of fluorescein, pyrogallol selleck kinase inhibitor red, and BODIPY induced by peroxyl radicals. Furthermore, the antioxidant capacity against lipid peroxidation was assessed in the oxidation of methyl linoleate induced by free radicals in micelle systems. Cysteine, homocysteine, and glutathione exhibited considerable reactivity toward galvinoxyl, DPPH, and peroxyl radicals in this order but methionine did not. Bovine serum albumin (BSA)

was less reactive toward these radicals than cysteine on molar base. Cysteine, homocysteine, and glutathione suppressed the oxidation of methyl linoleate in micelle systems, but methionine did not. The reactivity toward free radicals and antioxidant capacity of these thiol compounds were less than that of ascorbic acid, but higher than that of uric acid.”
“BACKGROUND: Equilibrium studies were carried out with the aim of finding the basic design parameters for ion exchange plants using a glycerol phase obtained from biodiesel production. The uptake of sodium and potassium ions on a strongly acidic ion exchanger, Amberlite IR-120, in the proton form from glycerol/water mixtures has been studied. The effect on the selectivity towards sodium of the percentage of water in glycerine/water mixtures on the macroporous resin Amberlite 252 has been analyzed. Finally, chloride removal by a strongly basic anionic-exchange resin Amberlite IRA-420 at three different temperatures has been studied.

Single gene polymorphisms in cytochrome P450 2C9 (CYP2C9) and

Single gene polymorphisms in cytochrome P450 2C9 (CYP2C9) and

vitamin K epoxide reductase (VKORC1) have been shown to impact warfarin dosing in adults. Insufficient data exists on genetic and clinical factors which influence warfarin dosing in children. Pediatric patients with heart disease who received long-term warfarin therapy were tested for VKORC1 and PLX4032 CYP2C9 polymorphisms. Clinical and demographic data were reviewed in those children who achieved stable therapeutic international normalized ratio (INR). Multiple linear regression modeling was used to assess relationships between stable warfarin doses and genetic or clinical variables. Fifty children were tested for VKORC1 and CYP2C9 polymorphisms; 37 patients (M 26: F 11) had complete data, achieved stable therapeutic INR, and were included in dose variability analysis. There were predominance of white race 73% and male sex 70.3%. The mean age was 9.6 years (1.8-18.6 years). The mean weight was 37.8 kg (7.7-95 kg). Fontan physiology and mechanical

cardiac valves were two most common indications for chronic warfarin therapy (25/37 or 67.6%). Twelve patients (32.4%) had a parts per thousand yen2 indications for warfarin therapy. Three patients had documented venous or arterial clots, and 5 patients had strokes. Congenital heart disease was present in 29 patients (78.4%), including Fontan physiology (20), complex biventricular physiology (4), and congenital mitral

C188-9 GSK1210151A nmr valve disease (5). Acquired heart disease was present in 8 patients (21.6%), including Kawasaki disease with coronary aneurysms (3), acquired mitral valve disease (3), and Marfan syndrome (2). Stable warfarin dose (mg/kg/day) was strongly associated with VKORC1 polymorphism (p < 0.0001) and goal therapeutic INR (p = 0.009). Negative correlations were observed between stable warfarin dose and age, weight, height, and BSA (p = 0.04, 0.02, 0.02, and 0.02 respectively). Factors which did not influence warfarin dose included CYP2C9 polymorphism (p = 0.17), concurrent medications (p = 0.85), sex (p = 0.4), race (p = 0.14), congenital heart disease (p = 0.09), and Fontan physiology (p = 0.76). The gene-dose effect was observed in children with homozygous wild type VKORC1 CC, who required higher warfarin dose compared to those carrying heterozygous TC or homozygous TT (p = 0.028 and 0.0004 respectively). The full multiple linear regression model revealed that VKORC1 genotypes accounted for 47% of dosing variability; CYPC29 accounted for 5%. Overall, the combination of VKORC1, CYP2C9, age, and target INR accounted for 82% of dosing variability. In children with heart disease, VKORC1 genotypes, age, and target INR are important determinants influencing warfarin dosing in children with heart disease. Future warfarin dosing algorithm in children should factor both genetic and clinical factors.”

Specialized wound care may be needed when irradiation exceeds 10

Specialized wound care may be needed when irradiation exceeds 10 Gy. Residual effects from radiation therapy and this website from previous procedures influence the response of skin and subcutaneous tissues to subsequent procedures. Skin irradiated to a dose higher than 3-5 Gy often looks normal but reacts abnormally when irradiation is repeated. If the same area of skin is likely to be exposed to levels higher than a few grays, the effects of previous irradiation should be included when estimating the expected tissue reaction from the additional procedure.”
“Gynura bicolor DC. is a traditional vegetable in Japan. G. bicolor grown in the field has adaxial sides of

leaves that are green and abaxial sides that are reddish purple. It has been reported that the responsible JIB-04 Epigenetics inhibitor reddish purple pigments are anthocyanins, which are acylated and highly stable. We have reported

that cultured G. bicolor plantlets treated with methyl jasmonate (MJ) exhibited anthocyanin accumulation in roots, and this was affected by light irradiation. In the present study, to clarify this accumulation induced by MJ treatment, we isolated anthocyanin biosynthesis and regulatory genes from G. bicolor. Expression analysis revealed up-regulated expression of flavonoid biosynthesis genes, GbCHS, GbCHI, GbDFR and GbANS. Furthermore, it was shown that isolated regulatory genes, GbMYB1 and GbMYC1, were also upregulated by MJ treatment. In addition, it was shown that co-expression of GbMYB1 and GbMYC1 could activate GbDFR and GbANS gene promoters in transient assays with tobacco protoplasts. These results strongly indicate that GbMYB1 and GbMYC1 coordinately regulate flavonoid biosynthetic genes induced by MJ treatment, and thereby cause anthocyanin accumulation in roots. (C) 2010 Elsevier Masson SAS. All rights reserved.”
“Aims: To investigate trends in rates of ecstasy use among US adolescents from 1999 to 2008, and to examine the

associations between the major sociodemographic factors, especially gender, and ecstasy use, during this period.

Methods: The adolescent subsamples (age 12-17) from 1999 to 2008 NHSDA/NSDUH surveys were used for the current study. Data from adolescents’ self-reports on use of ecstasy and of other drugs, as well as sociodemographic characteristics, were used in the analyses.

Results: There was an increasing trend in adolescent ecstasy buy CRT0066101 use from 1999 to 2002, which was followed by a decreasing trend from 2002 to 2005, and a slight rise from 2005 to 2008. In contrast to some other drugs, ecstasy was more likely to be used by girls than by boys. This gender difference persisted over the 10-year period and could not be explained by other demographic factors.

Conclusion: Given the known health consequences of ecstasy use, especially for females, the observed gender difference in adolescent ecstasy use should be taken into account by drug prevention and intervention programs. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

The incidence in “”no risk”" and “”at risk”" group was 2 27 per 1

The incidence in “”no risk”" and “”at risk”" group was 2.27 per 1000 screened and 49.18 per 1000 screened respectively. Statistically significant difference in the incidence of hearing impairment between the two groups. (P < 0.05; Proportion Test) was seen. Common risk factors identified were culture positive Panobinostat postnatal infections, birth asphyxia, low birth weight, and prematurity.


A high incidence of hearing impairment warrants the implementation of universal newborn hearing screening. Considering the economic limitations of our country we may employ screening of “”at risk”" groups initially. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“Background: There has been recent renewed interest in the use of metal-backed

glenoid components in total shoulder arthroplasty. However, little information is available on the long-term results. The purpose of this study was to determine the results, the risk factors for an unsatisfactory outcome, and the failure rates of total shoulder arthroplasty with a cemented metal-backed glenoid component.

Methods: Repotrectinib in vivo Between 1985 and 1991, 100 total shoulder arthroplasties with Neer cemented metal-backed glenoid components were performed at our institution to treat osteoarthritis. Ninety-five shoulders were followed for a minimum of two years (mean, 10.8 years) or until the time of revision surgery. Patients were assessed with use of a modified Neer rating system at the time of the latest follow-up. Radiographs of eighty-three shoulders were assessed for the presence

of glenoid erosion, glenohumeral subluxation, periprosthetic lucency, and a shift in component position.

Results: Total shoulder arthroplasty with a cemented metal-backed glenoid component was significantly associated with pain relief (p < 0.001) as well as with an improvement in abduction from a mean of 92 degrees to 146 degrees (p < 0.001) and external rotation from a mean of 26 degrees to 60 degrees (p < 0.001). According to the modified Neer result-rating system, the result was excellent in forty-seven shoulders, satisfactory in twenty-seven shoulders, and unsatisfactory in twenty-one shoulders. Five patients underwent revision surgery because of component Nutlin-3a supplier loosening (two patients), component subluxation (one patient), a fracture distal to the stem (one patient), and polyethylene wear (one patient). Glenoid periprosthetic lucency was present in sixty-nine (83%) of eighty-three shoulders at a minimum radiographic follow-up of two years.

Conclusions: The data from this study suggest that total shoulder arthroplasty with a cemented metal-backed glenoid component for the treatment of osteoarthritis is associated with pain relief and improvement in motion. However, the high rate of glenoid periprosthetic lucency is concerning and requires additional follow-up and investigation. These results are not better than those that have been reported for all-polyethylene cemented glenoid components.