Conclusions. FBT showed continued clinically important analgesic effects and was generally well tolerated over 12 weeks of treatment.”
“Many genetic variants have been shown to affect drug response through changes in drug efficacy and likelihood of adverse effects. Much of pharmacogenomic science has focused on discovering and clinically implementing single gene variants with large effect sizes. Given the increasing complexities of drug responses and their variability, a systems approach may be enabling for discovery of new biology in this area. Further, systems approaches may be useful in addressing challenges Alvocidib cost in moving these data to clinical implementation, including creation of predictive

models of drug response phenotypes, Selleck Belnacasan improved clinical decision-making through complex biological

models, improving strategies for integrating genomics into clinical practice, and evaluating the impact of implementation programs on public health. WIREs Syst Biol Med 2014, 6:125-135. doi: 10.1002/wsbm.1255 For further resources related to this article, please visit the . Conflict of interest: The authors have declared no conflicts of interest for this article.”
“Objective: To understand how handling of missing data influences the statistical power and bias of treatment effects in randomised controlled trials of painful knee osteoarthritis (OA).

Methods: We simulated trials with missing data (withdrawals) due to lack-of-efficacy. Outcome measures were response/non-response according to the Outcome Measures in Rheumatology Osteoarthritis Research Society International (OMERACT-OARSI) set of responder criteria, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

pain and physical function from the WOMAC questionnaire, and patient global assessment. We used five methods for managing missing data: ignoring the missing data, last and baseline observation carried forward (LOCF and BOCF), and multiple imputation with two different strategies. The treatment effect was then analysed by appropriate Bucladesine univariate and longitudinal statistical methods, and power, bias and mean squared error (MSE) was assessed by comparing the estimated treatment effect in the trials with missing data with the estimated treatment effect on the trials without missing data.

Results: The best imputation method in terms of high power and low bias/MSE was our implementation of regression multiple imputation. The most conservative method was the data augmentation Markov chain Monte Carlo (MCMC) multiple imputation. The LOCF, BOCF and the complete-case methods were not particularly conservative and gave relatively low power and high bias. The analysis on the WOMAC pain scale gave less bias and higher power than the OMERACT-OARSI responder outcome measure.

Conclusions: Multiple imputation of missing data may be used to decrease bias/MSE and increase power in OA trials.

frederiksbergense were achieved. Using the present system, complete

degradation of pyrene was attained even at its very high initial Baf-A1 concentration and within a short time period. Further advantage offered by this system seems to be negligible toxic effect of pyrene and solvents on the degrading microorganisms since these were in an encapsulated form and were not in direct contact with the organism. (C) 2010 Society of Chemical Industry”
“The study reported here is a rare case of fetal sinus bradycardia that evolved into symptomatic bradycardia after birth, at which time the implantation of a cardiac pacemaker was indicated. Fetal echocardiography was used to diagnose the type of cardiac rhythm that caused the PARP inhibitor intra-uterine bradycardia, which enabled the initiation of the appropriate therapy approach and avoided an unnecessary interruption of the pregnancy. However, the details of the sinus bradycardia were impossible to determine in utero in this case due to

sinus node dysfunction. After birth, the electrocardiogram results drew attention to a potentially unusual cause of sinus bradycardia, and enabled the diagnosis of this rare disease in this infant.”
“BACKGROUND: Linoleic acid, which is a major derivative generated from hydrolysis of vegetable oils, is often found at high concentration in food processing and kitchen wastes. This fatty acid could be introduced into an anaerobic system treating piggery wastewater via co-digestion strategy. In this study, the effect of CaCl(2) on the inhibitory behavior of linoleic acid in LEE011 purchase the anaerobic digestion of piggery wastewater was investigated.

RESULTS: Linoleic acid exerted strong inhibitory effects on methanization of piggery wastewater with IC(50) of 376 mg L(-1) and 568 mg L(-1) for ISR (inoculum substrate ratio) 0.38 and 2.0, respectively.

Among tested cations (Na(+), Mg(2+), Ca(2+), Al(3+) and Fe(3+)), only Ca(2+) effectively reversed linoleic acid inhibition. In addition, it was found that CaCl(2) restricted linoleic acid inhibition only when it was added before or immediately after linoleic acid addition. Without CaCl(2), linoleic acid was stoichiometrically transformed to oleic acid, which persisted for a prolonged period. In the presence of CaCl(2), however, linoleic acid was completely converted to methane without accumulation of oleic acid. It was also found that oleic acid was self-inhibitory to its oxidation to acetate, and CaCl(2) removed this inhibition.

CONCLUSION: From these findings, it was concluded that calcium ion not only mitigated linoleic acid inhibition in the anaerobic digestion of piggery wastewater, but also enhanced its mineralization to methane.

0 mg/kg SQ) and diphenhydramine (2.0 mg/kg SQ) 20 min prior to butorphanol [n = 6] (0.2 mg/kg IV) or propofol [n = 6] (4 mg/kg IV bolus, 0.2 mg/kg/min CRI). Standard color and red-free images were obtained prior to administration of 10% sodium fluorescein (20 mg/kg IV). Image acquisition was performed using a dSLR camera (Canon 7D), dSLR camera adaptor, camera lens (Canon EF-S 60 mm f/2.8 macro),

and an accessory flash (Canon 580EXII). Imaging occurred at a rate of 1/s immediately following bolus for a total of 30 s, then at 1, 2, 3, 4, 5, and 10 min. Results Twelve dogs with a combined mean age of 5.1 years and various iris colors were imaged. Arterial, capillary, and venous phases were identified and time sequences recorded. Visibility Dibutyryl-cAMP of the vascular pattern was inversely related to iris pigmentation. Complete AMN-107 mw masking of blood

flow was noted with heavily pigmented irises. Vessel leakage was noted in some eyes. Proper patient positioning and restricted ocular movements were critical in acquiring quality images. No adverse events were noted. Conclusion This study demonstrated that quality high resolution ASFA images were obtainable using a novel dSLR camera adaptor. ASFA of the normal canine eye is limited to irises, which are moderately to poorly pigmented. Use of general anesthesia produced higher quality images and is recommended for ASFA in the dog.”
“Sternal wound complications following median sternotomy remain a challenge in cardiac surgery. Changes in both patient profile and type of operations have been observed in recent years. Therefore, we analysed current wound healing complications after median sternotomy at selleck chemical our centre.

All adult patients undergoing a median sternotomy between January 2009 and April 2011 were included in this retrospective analysis. Transplants and assist devices implantations were omitted. We assessed outcome, prognostic factors and microbiological results of standardized wound swabs.

In total, 1297 patients with an average age of 67.0 +/- 12.7 years were analysed. Operation types included 598 solitary coronary artery bypass grafts (CABGs), 213 solitary valve procedures, 105 CABGs with aortic valve replacement and

116 solitary aortic operations or conduit implantations. Furthermore, 255 of the remaining 265 were combined or otherwise complex procedures. Superficial healing disorders occurred in 43 patients (3.3%), while 33 (2.5%) developed deep wound complications. Six patients with sternal wound complications (7.9%) died in-hospital. In 7 patients, no pathogen was identified and the wound appeared uninfected (21% of all deep complications or 0.05% of all patients). These healing disorders were considered deep dehiscences. Patients with insulin-dependent diabetes mellitus, BMI of > 40 kg/m(2) and who underwent reoperation were prone to superficial infections. Risk factors for all deep sternal wound complications were insulin-dependent diabetes mellitus, COPD and reoperation.

Rhabdomyolysis events were reported per 10,000 person-years of LLD exposure; multivariate analysis was conducted.

RESULTS: The study cohort (N = 473,343) received 490,988 and 11,624 person-years of LLD, and combination therapy, respectively. Medical charts were obtained for 104 of 144 eligible patients with rhabdomyolysis claims; 42 cases were confirmed. With atorvastatin as reference, rhabdomyolysis

rates (95% confidence interval) were greatest for cerivastatin, 8 4 (2.3-21.7); no difference among available statins was observed. Rates for other LLD monotherapies were: niacin, 2.1 (0.3-7.7), ezetimibe, 2.1 (0.3-7.8), fenofibrate, 0 (0-1.7), and gemfibrozil, 2.0 (0.5-5.2). Multivariate analysis showed only cerivastatin with a significantly greater risk of rhabdomyolysis (odds ratio 4.74, 95% confidence interval 1.1-21.2, P = .041) versus atorvastatin among the statins. Combination MI-503 therapies PLX4720 had increased rhabdomyolysis risk (OR 7.1, 1.6-31.6, P = .010) versus LLDs alone.

CONCLUSION: The risk of habdomyolysis among hospitalized patients receiving statins was low; no difference among the available statins was evident. Further

data are needed to establish the risk profile but current findings already offer guidance to physicians. (C) 2013 National Lipid Association. All rights reserved.”
“Purpose of review

To provide an update on recently discovered human deafness genes and to describe advances in comprehensive genetic testing platforms for deafness, both of which have been

enabled by new massively parallel sequencing technologies.

Recent findings

Over the review period, three syndromic and six nonsyndromic AG-014699 chemical structure deafness genes have been discovered, bringing the total number of nonsyndromic deafness genes to 64. Four studies have shown the utility of massively parallel sequencing for comprehensive genetic testing for deafness. Three of these platforms have been released on a clinical or commercial basis.

Summary

Deafness is the most common sensory deficit in humans. Genetic diagnosis has traditionally been difficult due to extreme genetic heterogeneity and a lack of phenotypic variability. For these reasons, comprehensive genetic screening platforms have been developed with the use of massively parallel sequencing. These technologies are also accelerating the pace of gene discovery for deafness. Because genetic diagnosis is the basis for molecular therapies, these advances lay the foundation for the clinical care of deaf and hard-of-hearing persons in the future.”
“Introduction There is increasing awareness of the need for pedicle screw constructs in the treatment of spinal deformities in very young children. However, the long-term effects of pedicle screws on the immature spine are still unclear. We used a porcine model to analyze the morphological changes of the spinal canal and vertebral body in response to the placement of pedicle screws.

Methods 13 newborn pigs were operated on. Each pig received a single pedicle screw at the L2 level.

All were treated for haematological cancer, 3/7 received haematopoietic stem cell transplantation (HSCT), and 4/7 received rituximab. Using multivariate analysis, receiving > 1 line of CT was an independent risk factor for HBV-R. Fatal outcome occurred in 3/7 patients (despite lamivudine therapy in two), whereas 2/4 survivors had an HBsAg seroconversion. HBV-R involved non-A HBV genotypes and core promoter and/or precore HBV mutants in all cases. Mutations known to impair HBsAg antigenicity

were detected in HBV DNA from all seven patients. HBV DNA could be retrospectively detected in two patients prior cancer treatment and despite HBsAg negativity. HBV-R is a concern in HBsAg-negative/anti-HBcAb-positive patients undergoing selleck compound cancer therapy, especially in males presenting with haematological cancer,

a low anti-HBsAb titre and more than one chemotherapeutic agent. HBV DNA testing is mandatory to improve diagnosis and management of HBV-R in these patients. The role of specific therapies such as rituximab or HSCT as well as of HBV aa variability deserves further studies.”
“Background: Adequate fibrinogen concentration is a crucial component of sufficient perioperative/posttraumatic hemostasis. In major blood loss, C59 manufacturer large volumes of fluids are being administered, which have been shown to interfere with valid determination of fibrinogen concentration. This may lead to wrong treatment decisions. We studied the variables that cause the discrepancies between measured and true fibrinogen concentrations in

samples diluted with volume replacement fluids. Methods: Citrated plasma samples of healthy volunteers were diluted by 30% and 50% with phosphate buffered saline (PBS), hydroxyethyl starch (HES) 10% (200/0.5), or gelatine (GEL). Fibrinogen concentrations of diluted samples were derived from the prothrombin time (PT) and the Clauss method (CLS) was applied. With the latter, several modifications and combinations of detection principles and thrombin reagents were investigated. Values were compared with “”true,”" that is, calculated values based on the results of undiluted Buparlisib mouse samples for each method. Results: Photo-optical methods resulted in significant overestimation of the fibrinogen concentration in blood diluted with HES, depending on the thrombin reagent used. This was particularly true for modifications of the CLS aimed at measuring low fibrinogen concentrations. Use of another thrombin reagent gave satisfactory results for this modification. The validity of mechanical end point determination methods was considered sufficient and was not influenced by the use of different thrombin reagents. Conclusions: Fibrinogen determination methods used in situations of major blood loss need to be validated with samples containing significant amounts of volume replacement fluids, particularly colloids.

(C) 2013 Elsevier B.V. All rights reserved.”
“Purpose of review

Training in percutaneous nephrolithotomy (PCNL) necessitates the trainee to climb

the steep learning curve of this procedure sequentially. The initial steps of the process should be the acquisition of the necessary skills in a nonintimidating skills lab. We review the current scenario of the training in PCNL and advocate ACY-241 research buy the means that may improve the overall patient care.

Recent findings

The training involves a comprehensive development of the trainee. Initial process starts with the cognitive skills update through conferences and observing peers do the procedure. Rapid prototyping could be useful for resident education. The benefits of three-dimensional stereolithographic biomodeling produced from computed tomography data may aid in achieving optimal access. Skills lab involving wet and dry lab reinforce the cognitive skills. The advantage of live anesthetized porcine model is it being a more

realistic model and assessment tool. The specific advantage of the dry lab simulator is of repetitive tasking and easier setup feasibility. There is a lack of guideline for the lab setup and training. Funding, location, number of models installed, curriculum, a trained mentor, and instructor are the critical components that need to be planned in advance.

Summary

Training in PCNL starts with cognitive knowledge, reinforcement through repetitive nonpatient basic skills acquisition in wet and dry skills lab, Foretinib datasheet prototyping the technique before the actual procedure, and finally supervised training under an able mentor.”
“Introduction: Evidence supports the introduction of an abdominal aortic aneurysm (AAA) screening programme. The aims of this study were to estimate future disease patterns and to determine the effect of the proportion attending on the programme’s cost-effectiveness.

Patients and methods: The results of the local AAA ACY-241 screening programme were reviewed. Ultrasonic

infrarenal aortic diameter of 30 mm was considered aneurysmal. Projected population numbers from the Department of Health and current disease prevalence were used to estimate future number of potential patients. The Multi-centre Aneurysm Screening Study (MASS) Markov model was used to calculate an incremental cost-effectiveness ratio (ICER) and 95% uncertainty intervals (UI), using a 30-year time horizon and 3.5% per annum discount, to determine the effect of attendance.

Results: Men were recruited from August 2004 to May 2010. 13316 were invited for a scan and 5931 (44.5%) attended. 321 AAA were diagnosed, giving a prevalence of 5.4%, while 27 large AAA (0.46%) were repaired. The annual incidence of AAA until 2021 will range from 441 to 526, with an incidence of 40-48 large AAA, with both showing a gradual increase with time.

005] per minute t(1/2)). Gastroparesis is common in lung-transplant recipients and associated with the development of BOS.”
“We describe a case of fatal acute disseminated breakthrough toxoplasmosis in a 19-year-old adolescent after haploidentical hematopoietic stem cell transplantation for acute lymphoblastic leukemia despite continued atovaquone prophylaxis. Diagnosis was at necropsy, and confirmed by postmortem polymerase chain

reaction analysis in plasma. This report illustrates the need for protozoal monitoring GSK’872 cost despite atovaquone prophylaxis, in severely immunocompromised patients with intolerance to standard treatment.”
“We have theoretically investigated the electronic subband structures and thermoelectric transport properties of Bi nanotubes. The calculated semimetal to semiconductor transition in Bi nanotubes is in good agreement with experiment results. The expressions for Seebeck coefficient and the optimized carrier

concentration are first derived, and have been used to explain the calculated and experimental results. The effects of thickness, diameter, and growth direction of Bi nanotubes and carrier concentration on the thermoelectric figure of merit (ZT) are discussed. It was found that the Bi nanotube oriented along the trigonal direction has the highest SBC-115076 solubility dmso ZT, and the optimized carrier concentration is found to be in a range from 10(18) cm(-3) to 4.0 x 10(18) cm(-3). The predicted enhancement in ZT is important for the anticipated applications of Bi nanotubes for thermoelectric devices. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3593193]“
“Introduction: RG-7112 datasheet The impact of renal replacement therapy (RRT) in living donor liver transplantation (LDLT) has not yet been investigated.

Methods: Among 253 LDLT patients, RRT was started before (RRT-Pre, n = 9), or after (RRT-Post, n = 27) LDLT. The clinical outcomes were reviewed.

Results: The one-yr graft survival rate was 94.1% without RRT, and

63.9% and in those with RRT (p < 0.0001). Among the RRT patients, the RRT-Pre patients exhibited acute liver failure, hepatorenal syndrome and high model for end-stage liver disease score (35 +/- 12), whereas the RRT-Post patients had sepsis as a comorbidity. The one-yr graft survival rate was 100.0% in the RRT-Pre patients vs. 51.9% in the RRT-Post patients (p < 0.01). The duration of RRT was significantly shorter in the RRT-Pre patients than that in the RRT-Post patients (5.3 +/- 2.1 vs. 17.8 +/- 14.1 d, p = 0.02). The mean duration between starting RRT and LDLT was 2.1 +/- 0.7 d in the Pre-RRT patients.

Conclusion: The RRT-Pre patients had excellent outcomes because the severe condition was primarily treated by LDLT after short-term pre-transplant RRT. Post-transplant uncontrollable sepsis was the major cause of graft loss in patients who receive RRT after LDLT.”
“We perform a first-principles calculation to investigate the effect of a vacancy on the sliding of an iron (Fe) Sigma 5 (310) [001] tilt grain boundary (GB).

Methods: Scientific articles published from 1967 to 2013 in the PubMed/Medline, ISI Web of Knowledge, Cochrane, and SciELO databases were reviewed.

Results: Saccadic eye movement appears to be heavily involved in psychiatric diseases covered in this review via a direct mechanism.

The changes seen in the execution of eye movement tasks in patients with psychopathologies of various studies confirm that eye movement is associated with the cognitive and motor system.

Conclusion: Saccadic eye movement changes appear to be heavily Pevonedistat involved in the psychiatric disorders covered in this review and may be considered a possible marker of some disorders. The few existing studies that approach the topic demonstrate a need to improve the experimental paradigms, as well as the methods of analysis. Most of them report behavioral variables (latency/reaction time), though electrophysiological measures are absent.”
“An analysis of dynamic roughening and smoothening mechanisms of thin https://www.selleckchem.com/screening-libraries.html films grown with pulsed-dc magnetron sputtering

is presented. The roughness evolution has been described by a linear stochastic equation, which contains the second- and fourth-order gradient terms. Dynamic smoothening of the growing interface is explained by ballistic effects resulting from impingements of ions to the growing thin film. These ballistic effects are sensitive to the flux and energy of impinging ions. The predictions of the model are compared with experimental find more data, and it is concluded that the thin film roughness can be further controlled by adjusting waveform, frequency, and width of dc pulses. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3037237]“
“Background: Patients with

lung adenocarcinoma who carry epidermal growth factor receptor (EGFR) gene mutations respond remarkably well to EGFR tyrosine kinase inhibitor (EGFR-TKI), gefitinib, or erlotinib. However, the effect of EGFR-TKI treatment on the prolongation of overall survival (OS) of these patients remains uncertain, although several recent studies have shown prolongation of progression free survival compared with cytotoxic chemotherapy.

Methods: A total of 304 patients with lung adenocarcinoma who had postoperative recurrent disease were studied. To eliminate potential biases as possible, the matching of four potential predictive factors of responsiveness to EGFR-TKI led to the identification of 81 pairs of patients (those who were treated with gefitinib and those who were not). A deletion mutation in exon 19 and a point mutation (L858R) in exon 21 of the EGFR gene were also analyzed. We compared the OS between the two groups.

Results: OS in the gefitinib group was significantly longer than in the control group (median, 63 vs. 41 months; p = 0.015).

This study provides some scientific bases for the use of this plant as a remedy for stomach, skin and bacterial infections P005091 supplier in folkloric medicine whose causative agents are some of the pathogens studies. The activities observed could be attributed to the presence of some of the phytochemicals detected which have been associated

with antibacterial activity and cytotoxic property.”
“Combining advanced transmission electron microscopy with high-precision first-principles calculation, atomic-scale structures of the LaAlO3/TiO2 interface are investigated and bridged to their electronic property at the atomic level. Experimentally, the deposited TiO2 thin film is demonstrated to have an anatase phase and bond directly to the LaAlO3 substrate in an epitaxial, coherent, and atomically abrupt fashion. The atomic-resolution microscopic images reveal that the interface can be terminated with either AlO2 or LaO layer, which is predicted in theory to exhibit a semiconducting or metallic nature at interface, respectively. By applying

several analytic methods, we characterize carefully the electronic structure and determine interfacial bonding to be of a mixed covalent-ionic character. The combined experimental and theoretical studies performed shed light on the complex atomic and electronic structures of the buried interface, which are fundamental KPT-330 cell line for understanding the promising properties of functional films for future electronics. c 2010 American Institute of Physics. [doi: 10.1063/1.3516496]“
“Ethyl caffeate (EC), octyl caffeate(OC), benzyl caffeate(BC) and phenethyl caffeate(PC) were synthesized and evaluated for scavenging of superoxide anion, nitric oxide radical and 1,1-diphenyl-1-picrylhydrazyl radical(DPPH). Antioxidant activity was investigated with reducing power method. Pooled human liver microsome was used for selleck chemicals llc investigating the effects on cytochrome P450 1A2 (CYP1A2) catalytic activities by using phenacetin as a substrate. Dixon and Cornish-Bowden

plots were used for enzyme kinetic analysis. The EC, OC, BC and PC potentially inhibited superoxide anion, nitric oxide and DPPH radicals. IC(50) values of superoxide anion scavenging of EC, OC, BC and PC were 16.42, 79.83, 123.69 and 123.69 mu g/ml, respectively. EC was more potent than OC and BC in terms of nitric oxide radical scavenger: IC(50) values of EC, OC and BC were 24.16, 37.34 and 52.64 mu g/ml, respectively. In addition, the IC(50) values of EC, OC, BC and PC on DPPH radical scavenging were 70.00, 184.56, 285.34 and 866.54 mu g/ml, respectively. The IC(50) values of EC, OC, BC and PC on phenacetin O-deethylation were 124.98, 111.86, 156.68 and 31.05 mu g/ml, respectively. Enzyme kinetics showed that the type of inhibition mechanism was mixed-type. The result of this study shows that caffeic acid ester analogues potentially scavenge free radicals and inhibit catalytic activity of CYP1A2.

In the vast majority of obese patients and those with Type 2 diabetes, circulating cortisol levels are not elevated. However, within key metabolic target tissues, the enzyme II beta-hydroxysteroid dehydrogenase type 1 (II beta-HSD1) converts the inactive glucocorticoid, cortisone, to cortisol, which is then available to bind and activate the glucocorticoid receptor and thus amplify local glucocorticoid action. In a series of in vitro rodent and clinical studies, II beta-HSDI has been validated as GW2580 nmr a therapeutic target, and currently almost all major pharmaceutical companies are investing in programmes developing selective II beta-HSDI

inhibitors. In rodent models of obesity and diabetes, these compounds increase insulin sensitivity, improve glucose tolerance and glycemic control, decrease

fasting insulin and lipid levels and decrease atherogenesis. Whilst they appear to be safe and well tolerated, clinical efficacy data on metabolic outcomes in humans have been slow to emerge and translation to the clinical setting remains the most pressing issue within the field. In this review, we present the evidence validating II beta-HSDI as a therapeutic target and summarize the reported data that describe the metabolic impact of selective II beta-HSDI inhibition.”
“Background Molar pregnancy is a complication of 1 in 2002000 pregnancies whereby abnormal placental tissue proliferates in the absence of a fetus and may lead to metastases. The check details disease origin lies in dispermy or dual fertilisation of the egg. The aim of this study was to explore the impact of molar pregnancy upon the male partner. Methods Institutional ethics committee approval and individual consent were obtained. All women listed on the state molar pregnancy database who were receiving active follow-up (n?=?102) and a random sample of women who had been registered in the previous 30?years

(n?=?56) were sent a postal survey outlining the purpose of the study and an invitation for their partner to participate. Sixty-six women gave permission for their partner to participate in the study. Questionnaires included the Hospital Anxiety and Depression Scale, Satisfaction with Life Scale and Sexual History Form 12. Responding partners were also selleck chemicals invited to make comments about any aspect of particular concern. A reminder mail out was issued after 6?weeks. Results The response rate was 62% (N?=?41). The key findings were that 32.5% and 12.5% of men met the case criteria for anxiety and depressive disorder, respectively. These figures represent a doubling of usual community rates for anxiety disorder. However, overall quality of life and sexual functioning outcomes were consistent with community samples. The presence of children played a protective role and was associated with significantly better psychological function and quality of life in univariate and multivariate analysis. Qualitative results complemented the quantitative data, with anxiety as the dominant emotional theme.