(Obstet Gynecol 2011;118:439-42) Go 6983 clinical trial DOI: 10.1097/AOG.0b013e318212f935″
“Objectives: To obtain objective data of bone conduction implant stability and osseointegration in children; to compare in pediatric subjects the stability and osseointegration of the novel TiOblast-coated implant system
(BI300) to the previous generation, as-machined model.
Study Design: Multicenter, controlled, nonrandomized, longitudinal, prospective study.
Setting: Tertiary referral center.
Level of Evidence: IIIb
Patients: Ten subjects were enrolled, aged younger than 16 years and without comorbidities that negatively affect osseointegration. All patients were implanted “”single stage”": 5 received the previous generation, pure titanium fixture (control group), and 5 were implanted the BI300, TiOblast-coated fixture (test group).
Interventions: Measurement of implant stability and osseointegration.
Main Outcome Measure(s): Implant stability and osseointegration as measured by means of resonance frequency analysis intraoperatively, Selleckchem mTOR inhibitor at 1 week, 2 weeks, 1 month, and every month till processor loading 6 months after surgery.
Results: BI300 is, on average, more stable than the control fixture, both intraoperatively and over time till processor loading. Over the 6 months’ follow-up, a stability increase was observed with both models, although it resulted statistically not significant.
Conclusion:
The BI300 implant system has a greater primary stability as compared with the previous generation model, but its faster osseointegration selleck kinase inhibitor could not be definitely verified. It is reasonable to assume that the BI300 fixture will enable surgeons to perform single-stage surgery more safely and with a lower failure rate. The possibility
of an earlier processor loading remains to be confirmed in a greater sample.”
“This study evaluated the combined effect of fluoride compounds and CO2 laser in controlling the permeability of eroded enamel. Bovine enamel slabs (3 x 2 mm) were cycled twice through an alternating erosion and remineralization regimen. Slabs were immersed in 20 ml of orange juice (pH 3.84) for 5 min under agitation, rinsed with deionized water, and stored in artificial saliva for 4 h to form erosive lesions. Specimens were then divided into four groups (n = 10), which were treated for 1 min with either a control or with one of the following gels: amine fluoride (AmF), titanium tetrafluoride (TiF4), or sodium fluoride (NaF). Half of the specimens were irradiated with a CO2 laser (lambda = 10.6 mu m; 2.0 W). Specimens were cycled two more times through the aforementioned erosion-remineralization regimen and were subjected to permeability assessment. ANOVA demonstrated a significant interaction between fluoride and laser treatment (p = 0.0152). Tukey’s test showed that when fluoride was applied alone, TiF4 resulted in lower enamel permeability than that observed after application of the placebo gel.