They further reported that silencing of NDRG2 attenuates p53-mediated apoptosis. These

data strongly suggested that NDRG2 was an important factor in regulating tumor cell apoptosis. Conclusions Our results show that enforced NDRG2 expression significantly inhibited RCC cell growth, and induced apoptosis in human renal carcinoma cells. We also observed that NDRG2 expression could be upregulated by p53 in dose dependent manner. Further research may help design an effective therapeutic modality to control renal cancer. Acknowledgements The Project Supported by Natural Science Basic Research Plan in Shaanxi Province of China (Program No. 2009JM4003-3) References 1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ: Cancer statistics, 2007. CA Cancer J Clin 2007, selleck compound 57:43–66.PubMedCrossRef 2. Boulkroun S, Fay M, Zennaro MC, Escoubet B, Jaisser F, Blot-Chabaud M, Farman N, Courtois-Coutry N: Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene. J Biol Chem 2002, 277:31506–31515.PubMedCrossRef 3. Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F, Ji S, et al.: N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. Int J Cancer 2003, 106:342–347.PubMedCrossRef 4. Qu X, Zhai Y, Wei H, Zhang C, Xing G, Yu Y, He F: Characterization and expression

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