The issue on the natural history of gastroesophageal reflux disea

The issue on the natural history of gastroesophageal reflux disease (GERD) is controversial. One pathogenesis model emphasizes the potential progression of GERD over time, other state demonstrated Dabrafenib cell line a very limited movement in between the 3 phenotypic presentations of GERD (Hershcovici

T., 2010, Malfertheiner P., 2012). Aim. To study the frequency of transformation of non-erosive reflux disease (NERD), erosive esophagitis and Barrett’s esophagus (BE) in elderly patients based on the results of five-year prospective study. Methods: We performed a prospective five-year observation of 891 elderly GERD patients (569 females, 322 males, median age 78,1 years). GERD was diagnosed on the basis of the Montreal Consensus (Vakil N et al., 2006). The Ku0059436 presence of erosive esophagitis was classified using Los Angeles classification (Lundell LR et al., 1999). During the five-year follow-up clinical examination and endoscopy of the esophagus were performed twice a year. Morphological examinations of the esophagus to determine BE were done in the beginning and the end of study. Results: A five-year prospective study in elderly patients showed an increase in the frequency of erosive esophagitis and BE and reducing of NERD frequency (Table 1). The

main risk factors for progressive course of GERD were obesity (OR = 2,23, CI 1,50–3,29; p < 0,001), hiatal hernia (OR = 5,2, CI 3,2–8,2; p < 0,001) and the lack of maintenance

proton pomp inhibitors therapy (OR = 6,1, CI 4,0–9,2; p < 0,001). Conclusion: The five-year prospective study has demonstrated that GERD is a progressive disease in elderly patients. Key Word(s): 1. GERD; 2. NERD; 3. erosive esophagitis; 4. Barrett's esophagus; Table 1. Five-year dynamics of GERD structure Pathology NERD Erosive esophagitis BE Abs. % Abs. % Abs. % Beginning of the study 472 52,9 357 40,1 61 7,0 In 5 years 335 37,6 471 52,9 85 9,5 OR; Cl; p 1,87; 1,56–2,26; <0,001 0,60; 0,49–0,72; <0,001 0,71; 0,51–1,0; 0,058 Presenting Author: SEOK-MIN PARK Additional Smoothened Authors: BYUNG-WOOK KIM, SEOK-CHEON YEOM, EUN-HEE SHIM, JEE-HEE KIM Corresponding Author: BYUNG-WOOK KIM Affiliations: Incheon St. Mary’s Hospital, The Catholic University of Korea Objective: The lifestyle changes accompanied by economic growth have influenced disease patterns in Korea. The aim of this study was to evaluate the changing patterns of peptic ulcer disease (PUD) over the past two decades in Korea. Methods: Serial multi-center surveys on lifestyles of peptic ulcer patients immediately after esophagogastroduodenoscopy (EGD) were performed in 1988–1989, 1996–1997, and 2011–2012 in 8 institutes affiliated with The Catholic University of Korea (Seoul St. Mary’s Hospital, Yeouido St. Mary’s Hospital, Uijeongbu St. Mary’s Hospital, Bucheon St. Mary’s Hospital, St. Paul’s Hospital, Incheon St.

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