(J Am Vet Med Assoc 2009;235:960-966)”
“Background: The relationship between sleep and mood regulation is well known, and some reports suggest a key role of sleep-related breathing disorders (SRBD) in the development of the symptomatology of depression, even if no conclusive data are actually found in the clinical literature. The aim of this study was to assess the relationship between SRBD and depressive symptoms in a population of school-aged children.
Methods: The study population comprised Tubastatin A 94 children affected by SRBD and 107 healthy children. To identify the severity of SRBD, an overnight respiratory evaluation was performed. All subjects filled out the Italian version of the Children Depression
Inventory (CDI) to screen for the presence of depressive symptoms.
Results: The group with SRBD showed higher CDI scores than the group without SRBD, with a positive correlation found between CDI scores, click here apnea-hypopnea index, and oxygen desaturation index values. Logistic regression showed that an apnea-hypopnea index >= 3 and an oxygen desaturation index >= 1 could be
risk factors for development of depressive symptoms. According to receiver-operating characteristic curve analysis, the cutoff point for the apnea-hypopnea index that could cause a pathological CDI score (> 19) was >5.66, and the cutoff point for the oxygen desaturation https://www.selleckchem.com/products/kpt-8602.html index was >4.2. The limitations of this study are that our data are derived from one single psychometric test and not from a complete psychiatric evaluation, and our subjects came from a small group in southern Italy.
Conclusion: Our results suggest the importance of mood assessment in children affected by SRBD.”
“The efficacy of second-line chemotherapy for relapsed primary peritoneal serous carcinoma has been numerously reported,
but reports on durable response after second-line therapy have been rare. We report the case of a 66-year-old woman with relapsed primary peritoneal serous carcinoma who showed durable response after just one cycle of second-line belotecan-based therapy. The response might be a complete pathologic remission. Considering the fact that our patient suffered from neutropenic sepsis during her treatment, we concluded that belotecan-based chemotherapy could be a good option for second-line chemotherapy in some selected patients, so patient selection should be carefully performed due to the toxicity of belotecan.”
“Objective-To describe clinical characteristics, treatment, and outcome of dogs with inflammatory carcinoma (IC) and identify patient-, tumor-, and treatment-related factors associated with overall survival time.
Design-Retrospective case series.
Animals-43 client-owned dogs.
Procedures-Records of dogs with a clinical diagnosis of IC that had histologic evidence of dermal lymphatic invasion were reviewed.