High-dose radiotherapy for oral cancer induces mandibular osteora

High-dose radiotherapy for oral cancer induces mandibular osteoradionecrosis with an incidence of approximately 5% to 20% [15, 16]. The SBI-0206965 manufacturer management of osteoradionecrosis is difficult and not always successful. Therefore, if the antitumor effect could be increased by combining chemotherapy with lower doses of radiotherapy, it might reduce radiation-related adverse events without sacrificing efficacy. The combined method studied here has the potential to increase the antitumor effect while minimizing surgery. Therefore,

a phase II study is warranted. On the other hand, the clinical response rate for neck nodal disease was 42.9%. This result was poor compared with the clinical response rate of the primary tumor. A late phase II clinical study of S-1 alone found a clinical response rate was 21.7% for cervical lymph node metastasis [13]. These results have suggested that neck dissection is warranted for metastatic lymph nodes in patients with oral carcinoma. In conclusion, the concurrent administration of S-1 and radiotherapy was well tolerated and yielded sufficiently positive results. The RD of S-1 with concurrent radiotherapy for this protocol is BSA <1.25 m2, 50 mg/day; BSA 1.25-1.5 m2, 80 mg/day; BSA ≥ 1.5 m2, 100 mg/day for 5 days per week for 4 weeks. We have already started a phase II study Selleckchem LY411575 in multiple institutes. Conflict of interests The authors declare that they have no competing interests.

Acknowledgements We thank Professor J. Patrick Barron of the International Medical Communications Center of Tokyo Medical University for his review of an earlier version of this manuscript. Electronic supplementary material Additional file Sitaxentan 1: Prevalence of adverse events (DOCX 123 KB) selleck compound References 1. Klug C, Berzaczy D, Voracek M, Millesi W: Preoperative chemoradiotherapy in the management of oral cancer: A review. J Cranio-Maxillofac Surg 2008, 36:75–88.CrossRef 2. Kirita T, Ohgi K, Shimooka H, Yamanaka Y, Tatebayashi S, Yamamoto K, et al.: Preoperative concurrent chemoradiotherapy plus radical surgery for advanced squamous cell carcinoma of the oral cavity: an analysis of long-term results. Oral Oncol 1999, 35:597–606.PubMedCrossRef

3. Iguchi H, Kusuki M, Nakamura A, Nishiura H, Kanazawa A, Takayama M, et al.: Concurrent chemoradiotherapy with pirarubicin and 5-fluorouracil for respectable oral and maxillary carcinoma. Acta Otolaryngol Suppl 2004, 554:55–61.PubMed 4. Shirasaka T, Shimamoto Y, Ohshimo H, Yamaguchi M, Kato T, Yonekura K, Fukushima M: Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5- fluorouracil by two biochemical modulators. Anticancer Drugs 1996, 7:548–557.PubMedCrossRef 5. Fukushima M: Combines therapy with radiation and S-1, an oral new 5-FU prodrug, is markedly effective against nonsmall cell lung cancer xenografts in mice [Abstract].

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