Her studies include characterizing the role of tetrahydrobiopterin in the altered synthesis of NO in MSPH. Tamara Sáez: Miss Sáez (medical technologists) is a PhD in Biological Sciences
student at the Pontificia Universidad Católica de Chile. She is interested in the genesis and release of exosomes from the human placenta in gestational diabetes. Her studies include clarifying a potential regulatory function of released exosomes SB203580 cell line on the human placenta micro- and macrovascular endothelium. Andrea Leiva: Dr Leiva (biochemists) holds a PhD in medical sciences and is an Associated Researcher dedicated to study the involvement of maternal lipids levels in the fetoplacental vascular function in human pregnancy. Her research interest includes pregnancy pathologies related with alterations
in lipid metabolism such as GDM. Recent results suggest that maternal supraphysiological hypercholesterolemia leads to fetal endothelial Smoothened antagonist dysfunction in the micro- and macrovasculature of the human placenta with an altered modulation of l-arginine/NO and arginases/urea pathways in these cell types. Fabián Pardo: Dr Pardo (medical technologists) holds a PhD in molecular and cellular biology with expertise in the study of obesity and diabetes. At present, holds a postdoctoral position at CMPL, Faculty of Medicine, Pontificia Universidad Católica de Chile, studying fetoplacental endothelium dysfunction in obesity during pregnancy and GDM. His research regards the alterations of nucleoside membrane transport recycling in these diseases and proposes that gestational diabetes-associated reduction in human equilibrative nucleoside transporters activity involves their increased recycling
potentiated by supraphysiological gain of weight during pregnancy. Luis Sobrevia: Professor Sobrevia (biologists) holds Bay 11-7085 MSc in biological sciences and PhD in biomedicine and physiological sciences, and is focused in the study of fetoplacental vascular dysfunction in diseases of pathology, including GDM. He has proposed metabolic alterations in endothelial cells from the micro- and macrocirculation of the human placenta in GMD. The specific areas or research regards amino acids and nucleosides membrane transport mechanisms and the potential role of adenosine membrane receptors in the modulation of l-arginine transport and NO in these cell types. More recently, the role of insulin receptors as a key factor reversing GDM-associated alterations in human placental endothelium has been reported. “
“Please cite this paper as: Serre and Sasongko (2012). Modifiable Lifestyle and Environmental Risk Factors Affecting the Retinal Microcirculation. Microcirculation 19(1), 29–36. Structural changes within the human retinal vasculature may reflect systemic vascular changes associated with various cardiovascular and metabolic disorders.