g., a bag of groceries, a bag of garbage)? -9 of the 32 analyzed participants reported problems lifting. -Ability to lift sometimes limited as a result of lack of strength or fear of injury. 8. Reaching overhead in order to perform your day-to-day activities? -6 of the 32 analyzed participants reported problems reaching. 9. Picking things

up from the floor? -7 of the 32 analyzed participants reported problems bending down towards the floor. 10. Standing as much as you needed to in order to perform your day-to-day activities? -Stiffness occurring if the patient is in one position for too long. -Avoiding or BVD-523 cell line limiting the time spent standing as a result of pain. 11. Sitting as much as you needed to in order to perform your day-to-day activities? -Sitting for too long identified selleck chemical as a cause of pain. -8 of the 32 analyzed participants reported problems sitting. -Avoiding or limiting

the time spent sitting as a result of pain. -Stiffness occurring if the patient is in one position for too long. Transfers Relevant to all GSK2879552 molecular weight transfers domain items: 12. Getting in or out of bed? 13. Getting in or out of a chair? 14. Getting on or off the toilet? 15. Getting in or out of cars on your own? -Pain reported as affecting usual activities inside and outside the home. -Fractures as a result of osteoporosis can affect the ability to walk unaided and to complete daily activities unaided. Participants reported being unable to complete/needing help completing basic activities and self-care activities, Beta adrenergic receptor kinase even after the fracture had healed. -11 of the 32 analyzed participants reported problems getting up. First stage: cognitive debriefing Cognitive debriefing data showed that the interim version of OPAQ was well received but that a number of modifications were required. These included: (1) moving from a frequency response format to a severity response format; (2) making the introduction more informative and less likely to be overlooked; (3) adding a stem to the questionnaire to ensure participants responded specifically according to their osteoporosis

and not another comorbid condition; (4) removing groups of items that did not yield information regarding the impact of osteoporosis on physical function; (5) improving item wording; (6) subdividing items that asked about more than one issue (e.g., bending, lifting, and stooping); (7) adding new items identified as being of importance to osteoporosis patients; and (8) removing items considered irrelevant to osteoporosis patients. All modifications were tracked in an item-tracking matrix. The change in response option format was introduced because some participants found it difficult to determine how best to respond when the recall period was limited to 7 days and the options were limited to the two sets of responses that were used in the interim version of OPAQ.