As a result a consistent reduction in NTCP is achieved, with no l

As a result a consistent reduction in NTCP is achieved, with no loss in tumour control. Moreover our results

suggest that DIBH, with proper patient selection and training, is a practical and achievable solution for minimizing respiratory-induced target motion during both simulation and treatment. On the negative side the use of gating techniques with breath-hold increases treatment room occupation due to a more complex set-up. Treatment time is also increased when multiple breath-holds and consequent breathing recovery intervals are needed to complete the irradiation of a beam. However this latter side effect could be compensated by decreasing the beam-on time with an increase in the dose rate. Consent Written informed consent was obtained from the patient for the publication of this GW-572016 price report and any accompanying images. References 1. Edlund TGD: A single isocenter technique using CT-based planning in the treatment of breast cancer. Med Dosim 1999, 24:239–245.www.selleckchem.com/products/pf-03084014-pf-3084014.html PubMedCrossRef 2. Sidhu S, Sidhu NP, Lapointe C, Gryschuk G: The effects of intrafraction motion on dose homogeneity in a breast phantom with physical wedges, enhanced dynamic wedges, and

ssIMRT. Int J Radiat Oncol Biol Phys 2006, 66:64–75.PubMedCrossRef 3. Bortfeld T, Jokivarsi Vorinostat supplier K, Goitein M, Kung J, Jiang SB: Effects of intrafraction motion on IMRT dose delivery: statistical analysis and simulation. Phys Med Biol 2002, 47:2203–2220.PubMedCrossRef 4. Frazier RC, Vicini FA, Sharpe MB, Yan D, Fayad J, Baglan KL, Kestin LL, Remouchamps VM, Martinez AA, Wong JW: Impact of breathing motion on whole breast radiotherapy: A dosimetric analysis using active breathing control. Int J Radiat

Oncol Biol Phys 2004, 58:1041–1047.PubMedCrossRef 5. Hugo GD, Agazaryan N, Solberg Phloretin TD: The effects of tumor motion on planning and delivery of respiratory-gated IMRT. Med Phys 2003, 30:1052–1066.PubMedCrossRef 6. Pemler P, Besserer J, Lombriser N, Pescia R, Schneider U: Influence of respiration-induced organ motion on dose distributions in treatments using enhanced dynamic wedges. Med Phys 2001, 28:2234–2240.PubMedCrossRef 7. Schaly B, Kempe JA, Bauman GS, Battista JJ, Van Dyk J: Tracking the dose distribution in radiation therapy by accounting for variable anatomy Phys . Med Biol 2004, 49:791–805.CrossRef 8. Moody AM, Mayles WP, Bliss JM, A’Hern RP, Owen JR, Regan J, Broad B, Yarnold JR: The influence of breast size on late radiation effects and association with radiotherapy dose inhomogeneity Radiother . Oncol 1994, 33:106–112. 9. Chen MH, Chuang ML, Bornstein BA, Gelman R, Harris JR, Manning WJ: Impact of respiratory maneuvers on cardiac volume within left-breast radiation portals. Circulation 1997, 96:3269–3272.PubMedCrossRef 10.

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