Antigenic characteristics of glycated lysine residues in proteins

Antigenic characteristics of glycated lysine residues in proteins together with the presence of serum autoantibodies to the glycated lysine products and lysine-rich proteins in diabetes and arthritis patients indicates that these modified lysine residues may be a novel biomarker for protein glycation in aging and age-related diseases.”
“The high-pressure behavior of molybdenum trioxides (MoO3)

has been investigated by angle-dispersive synchrotron x-ray powder diffraction and Raman spectroscopy techniques in a diamond anvil cell up to 43 and 30 Cl-amidine cost GPa, respectively. In the pressure range of up to 43 GPa, structural phase transitions from the orthorhombic alpha-MoO3 phase (Pbnm) to the monoclinic MoO3-II phase (P2(1)/m), selleck and then to the monoclinic MoO3-III phase (P2(1)/c), occurred

at pressures of about 12 and 25 GPa at room temperature, respectively. Our observation of the transition from the orthorhombic alpha-MoO3 to the monoclinic MoO3-II phase is in disagreement with earlier studies in which the phase transition could not be obtained when only pressure is applied. The changes in the Mo-O distances and O-Mo-O and Mo-O-Mo angles may explain the changes in Raman spectrum. The pressure dependence of the volume of two monoclinic high-pressure phases is described by a third-order Birch-Murnaghan equation of state, which yields a bulk modulus value of B-0=143.41(3) GPa with B-0(‘)=12, and B-0=261.9(3) GPa with B-0(‘)=3.5.”
“SETTING: St Peter Tuberculosis (TB) Specialized Hospital and the Aklilu Lemma Institute of Pathobiology, Addis Ababa, Ethiopia.

OBJECTIVE: To genotype multidrug-resistant tuberculosis (MDR-TB) isolates and assess the magnitude of their clustering.

DESIGN: A total of 183 consecutive MDR-TB isolates collected between September 2009 and February 2012 were characterised using molecular typing. Prior to the study, the isolates were confirmed as MDR-TB using GenoType (R) MTBDRplus. Recent transmission index was used to analyse the clusters.


Spoligotyping identified 43 different patterns, Cell Cycle inhibitor of which 17 consisted of at least two isolates forming clusters, while 26 had only a single isolate. The most frequent patterns were spoligo international typing (SIT) number 21 and 149. Twenty-four patterns did not match existing patterns in the SpolDB4 database. The strains belonged to three lineages, the predominant lineages being Euro-American and Indo-Oceanic, each consisting of 65 isolates. High proportions (86%) of patients were infected with clustered strains, suggesting probable recent transmission of MDR-TB in the study area.

CONCLUSION: The observation of cluster formation of the spoligotype patterns of MDR-TB isolates could suggest transmission of MDR-TB strains among the population, thus warranting further attention.

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