7. Bibliography 1. Heilbron DC, et al. Pediatr Nephrol. 1991;5:5–11. (Level 4)   2. Coulthard MG. Early Hum Dev. 1985;11:281–92. (Level 4)   3. Schwartz GJ, et al.J Pediatr. 1984;104:849–54. (Level 4)   4. Schwartz GJ, et al.Pediatrics. 1976;58:259–63. (Level 4)   5. Brion LP, et al. J Pediatr. www.selleckchem.com/products/AZD8931.html 1986;109:698–707. (Level 4)   6. Schwartz GJ, et al. J Am Soc Nephrol. 2009;20:629–37. (Level 4)   7. Nagai T, et al. Clin Exp Nephrol. 2013 (Epub ahead of print). (Level 4)   8. Uemura O, et al. Clin Exp Nephrol. 2011;15:694–9. (Level 4)   Are the definition and staging of CKD in children the same as in adults? 1. Definition of CKD in children   The same definition for adult CKD

is used to diagnose children. Dinaciclib 2. Classification of CKD in children   In adults, the degree of proteinuria is also included in the staging of CKD based on data that showed correlation between the level of proteinuria and the prognosis. However, the degree of proteinuria in children is not as clearly correlated with the prognosis. Proteinuria is observed only in rare cases of CAKUT, the most common cause of stage 5 CKD in children. Moreover, there are no significant

data that suggest a relationship between kidney function and the degree of proteinuria in children. Hence, proteinuria is not currently used to classify CKD in children and the notations “G (= GFR)” and “A (= Albuminuria),” which are used in adult CKD staging, are not PLEKHB2 applied to CKD staging in children (Table 10). Children under 2 years of age typically have a low GFR even after correcting

for body surface area. Therefore, the aforementioned classification cannot be used for very young patients. Alternatively, a calculated GFR value based on serum creatinine can be compared with the normal age-appropriate values to detect kidney impairment. Bibliography 1. Heilbron DC, et al. Pediatr Nephrol. 1991;5:5–11. (Level 4)   2. Coulthard MG. Early Hum Dev. 1985;11:281–92. (Level 4)   3. Schwartz GJ, et al. J Pediatr. 1984;104:849–54. (Level 4)   4. Rhodin MM, et al. Pediatr Nephrol. 2009;24:67–76. (Level 4)   5. Uemura O, et al. Clin Exp Nephrol. 2011;15:694–9. (Level 4)   6. Wong CS, et al. Clin J Am Soc Nephrol. 2009;4:812–9. (Level 4)   Would a urinary screening program among school children be useful for improving the prognosis of CKD in children? Since 1974, a urinary screening program has been performed for all school children annually, which has contributed to the early detection of CKD in children in Japan. The prevalence of hematuria, proteinuria, and both abnormalities are approximately 0.75, 0.16, and 0.04 %, respectively, in elementary school children and approximately 0.98, 0.53, and 0.1 %, respectively, in junior high school students in Japan. Most children with chronic glomerulonephritis are identified by the urinary screening program at stage 1 CKD.