This parallels research in humans in which OT and social buffering interact to reduce CORT responses to a social stressor (Heinrichs et al., 2003). Other neuroendocrine changes have also been documented in response to social support. For example, the presence ABT-263 supplier of a conspecific in an open-field test reduces peripheral prolactin in male rats (Wilson, 2000). Relative to isolated individuals, socially housed female Siberian hamsters experience improved wound healing;

an effect which is mediated by oxytocin (Detillion et al., 2004). While little is known about the natural social organization of this hamster species (Wynne-Edwards and Lisk, 1989), wound healing has also been studied in three species of Peromyscus mice for which social organization is well characterized. In the two species of monogamous PD0332991 or facultatively monogamous Peromyscus mice, wound healing was facilitated by social contact. This was not the case in the promiscuous species, and this species

did not experience reduced CORT with pair-housing ( Glasper and DeVries, 2005). This suggests that social housing was beneficial only to the species that normally resides with a partner. Some recent findings in humans suggest that higher blood oxytocin and vasopressin levels may also be associated with faster wound healing in our species ( Gouin et al., 2010). Social environment

during stress has been shown to impact gastric ulcer formation in male rats following a stressor, however, only the social environment at the time of testing and not prior housing affected Rutecarpine ulcer frequency (Conger et al., 1958). Westenbroek et al. (2005) found that group-housed chronically stressed female rats had less adrenal hypertrophy than solitary-housed, stressed females. Social housing and support have also been shown to impact the function of the cardiovascular system. In humans, social support reduces heart rate and alters the ratio of systolic to diastolic blood pressure after performing stressful tasks (Lepore et al., 1993 and Thorsteinsson et al., 1998). In mice and prairie voles, social housing has been associated with lower heart rate (Späni et al., 2003 and Grippo et al., 2007), as well as other measures of cardiovascular health (Grippo et al., 2011). Not all social interactions are equal, and the effects of social companionship may differ by partner familiarity, sex, age, species, and affective state. Most studies of social buffering have explored one or two of these contexts at a time, but some evidence suggests that each of these can, but does not necessarily, impact the social buffering provided.