Table 1 Characteristics of the AS study population (n = 128) Age (years) 41.0 ± 11.1 Gender (male) (n, %) 93 (73) Disease duration (years) 14 (1–53) HLA-B27+ (n, %) 102 (84) NSAID use (n, %) 100 (78) DMARD use (n, %) 18 (14) BASDAI (range 0–10) 6.0 ± 1.6 BASDAI ≥ 4 (n, %) 116 (89) ESR (mm/h) 20 (2–90) Increased ESR (n, %) 95 (74) CRP (mg/L) 14 (2–92) Increased CRP (n, %) 99 (77) ASDAS 3.7 ± 0.8 SCH727965 ic50 BASFI (range 0–10) 5.6 ± 2.0 LS BMD T-score −0.68 ± 1.41 Osteopenia LS (n, %) 41 (39) Osteoporosis LS (n, %) 9 (9) Hip BMD T-score −0.52 ± 1.06 Osteopenia hip (n, %) 42 (39) Osteoporosis hip (n, %) 2 (2) VF (n, %) 41 (39)
VF grade 1 (n, %) 27 (25) VF grade 2 (n, %) 14 (13) VF see more grade 3 (n, %) 0 (0) PINP (μg/L) 42.7 (16.0–101.5) PINP Z-score 0.14 (−1.74–3.55) sCTX (pg/ml) 200.3 (13.4–780.9) sCTX Z-score −0.36 (−2.58–5.90) OC (μg/L) 12.7 (0.1–24.9) OC Z-score −0.28 (−2.86–2.52) 25OHvitD (nmol/L) 61.4 (13.8–186) Poor vitamin D status (n, %) 30 (26) Values are mean ± SD or median (range) unless otherwise indicated AS Ankylosing Spondylitis, HLA-B27+ human leukocyte antigen B27 positive, NSAID non-steroidal anti-inflammatory drug, DMARD disease-modifying antirheumatic drug,
BASDAI Bath Ankylosing Spondylitis Disease Activity Index, ESR erythrocyte sedimentation rate, CRP C-reactive protein, ASDAS ASAS-endorsed disease activity score, BASFI Bath Ankylosing Spondylitis Functional Index, LS lumbar spine, BMD bone mineral density, VF vertebral fracture, PINP procollagen type 1 N-terminal peptide, Hydroxychloroquine price sCTX serum C-telopeptides of type I collagen, OC osteocalcin, 25OHvitD 25-hydroxyvitamin D Correlations between biochemical and check details clinical assessments Correlations between BMD, BTM, vitamin D, and clinical assessments
of disease activity and physical function were calculated to obtain more knowledge about the pathophysiology of AS-related osteoporosis (Table 2). There was a significant positive correlation between lumbar spine and hip BMD T-scores. Lumbar spine BMD T-score positively correlated with BASDAI (p < 0.05) and hip BMD T-score negatively correlated with OC and sCTX Z-scores (p < 0.05).There were significant positive correlations between all BTM Z-scores. PINP Z-score positively correlated with age (p < 0.05), and PINP and sCTX Z-scores positively correlated with disease duration (p < 0.05). Finally, ESR, CRP, ASDAS, or BASFI were not significantly correlated with any of the BMD T-scores or BTM Z-scores. Table 2 Correlations between clinical and biochemical assessments in AS patients with active disease (n = 128) Age Disease duration BASDAI ESR CRP ASDAS BASFI PINP Z sCTX Z OC Z LS BMD T Hip BMD T Disease duration (years) 0.600a – BASDAI (range 0–10) NS NS – ESR (mm/h) NS NS NS – CRP (mg/L) NS NS NS 0.693a – ASDAS NS 0.187a 0.