Supporting data are largely from mixed populations of adolescents and adults, although ICS/LABA combinations
are not approved for adolescents in all countries. This analysis evaluates overall asthma control in asthma patients aged >= 16 years receiving ICS/LABA combinations.\n\nMethods: This was a post hoc analysis of asthma patients aged >= 16 years in a randomized, double-blind/open-label extension, parallel-group study. Patients received fixed maintenance-dose budesonide/formoterol (Symbicort (R) Turbuhaler (R)), fixed maintenance-dose salmeterol/fluticasone propionate (Seretide/Advair/Adoair (TM) Diskus (TM)) or adjustable maintenance-dose Selleck Mocetinostat budesonide/formoterol. Patients used terbutaline or salbutamol for as-needed reliever medication. The primary efficacy variable was the odds of having a well controlled asthma week during the randomized treatment period.\n\nResults: ICS/LABA regimens were well tolerated and efficacious, and the odds for achieving a well controlled asthma week did not differ between groups in this sub-analysis.
The number of exacerbations was similar between fixed-dose regimens; however, there were trends toward fewer exacerbations requiring hospitalization/emergency room treatment in the fixed- and adjustable maintenance-dose budesonide/formoterol groups (three and two events, respectively) than in the fixed-dose salmeterol/fluticasone propionate group (eight events). Improvements in forced expiratory volume in 1 second (FEV(1)) were small but significantly greater with fixed-dose budesonide/formoterol ACY-738 purchase versus fixed-dose salmeterol/fluticasone propionate.\n\nConclusions: This post hoc analysis
supports the use of ICS/LABA combinations in adults aged >= 16 years.”
“Lymphotoxin alpha (LTA) is a member of the TNF cytokine superfamily, produced principally by lymphocytes. It plays an important role in immune and inflammatory responses. Many TNF superfamily members have functionally important isoforms generated by find protocol alternative splicing but alternative splicing of LTA has never been studied. The known LTA protein is encoded by a transcript containing four exons. Here we report seven new LTA splice variants, three of them evolutionary conserved. We demonstrate their presence in cytoplasmic RNA suggesting that they could be translated into new LTA isoforms. We observed that their expression is differentially regulated upon activation of peripheral blood mononuclear cells and lymphocyte subpopulations (CD4+, CD8+, and CD19+). Our data suggest that the new LTA splice variants might play a role in the regulation of the immune response. (C) 2007 Elsevier Ltd. All rights reserved.”
“Disturbance of cholesterol homeostasis in the brain is coupled to age-related brain dysfunction.