Size differences Selleck PF-6463922 do not denote allelic variation, but

are determined by the criteria adopted to select the initiating methionine in ATCC17978 ORFs. Table 1 Gene products involved in pathogenicity in A.baumannii genomes Gene products         Strains       AB0057 AYE 3990 ACICU 4190 ATCC17978 3909 capsule formation               tyrosine kinase Ptk 91 3818 936 71 3295 49 2600 Tyrosine phosphatase Ptp 92 3817 935 72 3296 50 2601 type I pili formation               CsuE 2565 1324 787 2414 3382 2213 744 CsuD 2566 1323 786 2415 3383 2214 745 CsuC 2567 1322 785 2416 3384 2215 746 CsuB 2568 1321 784 2417 3385 2216 747 CsuA 2569 1320 783 2418 3386 2217 748 CsuA/B 2570 1319 782 2420 3387 2218 3415 iron metabolism               nonribosomal peptide synthetase BasD 2811 1095 2421 2579 tblastn 2383 1389 nonribosomal peptide synthetase BasC 2812 1094 2420 2580 3813 2384 tblastn ferric acinetobactin receptor 2813 1093 2419 2581 3814 2385 3376 ferric acinetobactin transport Fludarabine system periplasmic

binding protein 2814 1092 2418 2582 3815 2386 3375 ferric acinetobactin transport system ATP-binding protein 2815 1091 2417 2583 3816 2387 3374 ferric acinetobactin transport system permease 2816 1090 2416 2584 3817 2388 3373 ferric acinetobactin transport system permease 2817 1089 2415 2585 3818 2389 3372 hemin utilization               biopolymer transport protein ExbD/TolR 1827 2051 351 1629 227 1063 1994 biopolymer transport GDC-0994 cell line protein ExbD/TolR 1828 2050 352 1630 228 1064 1993 biopolymer transport protein 1829 2049 353 1631 229 1065 1992 TonB family protein 1830 2047 354 1632 230, 231 3708* 1991 TonB-dependent receptor 1831 2046 355 1633 232 1606, 1607 1990, 1989 heme-binding protein A 1832 2045 358 1634 234 1608 1987 heme-binding protein A 1833 2044 359 1635 235 1609 1986 Zn-dependent Rucaparib mouse oligopeptidase

1834 2043 360 1636 236 1610 1985 ABC-type dipeptide/oligopeptide/nickel transport system permease component 1835 2042 361 1637 237, 238 1611 1984 ABC-type dipeptide/oligopeptide/nickel transport system permease component 1836 2041 362 1638 239 1612 1983 glutathione import ATP-binding protein GsiA 1837 2040 363 1639 3719 1613 1982 * The asterisk indicates one of the 436 proteins putatively encoded by ATCC17978 not included in the GenBank:NC_009085 file. tblastn refer to unannotated 4190 and 3909 proteins identified by tblastn searches. Multidrug resistance is a key feature of A. baumannii and several genes have a role in establishing a MDR phenotype. Genes encoding efflux pumps and resistance proteins shown or hypothesized [26] to be involved in the process are conserved in all strains. In contrast, genes encoding drug-inactivating and drug-resistant enzymes reside in accessory DNA regions which are present only in some strains (Table 2).