Mononegative tetrahedral oxyanions are thus demonstrated to behave as general and effective tectons in anion coordination and anion-templated

assembly driven by halogen bonding.”
“Using a tight-binding model and some well-known approaches and methods based on Green’s function theory and Landauer formalism, APR-246 cell line we numerically investigate the conductance properties and I-V characteristics of (n,0) zigzag single-walled BCN alloy nanotube in the CNT/BCN/CNT structure, where nanocontacts are considered as (n,0) zigzag single-walled carbon nanotubes. Our calculations show that the conductance is sensitive to the it index. With I-V characteristics, this system can be a possible candidate for a nanoelectronic switching device. (C) 2009 Elsevier B.V. All rights reserved.”
“Background: Septic shock is common and has unacceptably high morbidity, mortality, and associated cost with numerous failed attempts at developing effective therapies. Endotoxin, one of the most potent mediators of sepsis, is found in high levels in approximately 50% of patients with septic shock. Polymyxin B (PMX) hemoperfusion has been shown in numerous studies to successfully

remove endotoxin and potentially improve outcomes. EUPHRATES (Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia Pfizer Licensed Compound Library and Septic shock) is a theragnostic trial (matching blood measurement to treatment capability) of PMX hemoperfusion in patients with septic shock and confirmed PF-04929113 endotoxemia as measured by the endotoxin activity assay (EAA). Methods: EUPHRATES is a pivotal regulatory trial that is multi-centered, placebo-controlled and blinded. The trial is being conducted in fifty ICUs in the United States and Canada and is powered to enroll 360 patients. Patients

with persistent septic shock despite adequate fluid resuscitation on vasopressors for more than 2 and less than 30 hours are eligible for measurement of the EAA. Those with EAA bigger than = 0.60 are eligible to be randomized to treatment with two sessions of PMX hemoperfusion 24 hours apart. The primary endpoint for the trial is 28-day all-cause mortality. Discussion: Unique features of the trial include absence of systemic inflammatory response (SIRS) criteria as a requirement for inclusion, use of the EAA to confirm endotoxemia as a requisite for treatment, and use of a detailed “facade” hemoperfusion event as a blinding mechanism. The outcomes of the second interim analysis included a resizing of the trial to 650 patients and the addition of an exclusion criterion of subjects with multiple organ dysfunction score (MODS) smaller than = 9. Results are anticipated in 2016.