5% of body mass loss) exercise can be prolonged to a greater extent than with water ingestion only [7]. Although speculative, AG ingestion may have augmented fluid uptake from the gut, and minimized the potential deleterious effects that mild levels of dehydration had on nerve conduction and brain function. These effects

may be more prevalent in activities involving multisensory information such as shooting (involves a coordinated and precise visual and motor control of the hands and arms) versus reaction of the lower body. In conclusion, rehydration with AG appears to maintain basketball skill LOXO-101 cell line performance and visual reaction time to a greater extent than water only. These effects are likely mediated by enhanced fluid and electrolyte HDAC inhibitor uptake from the gut and subsequent preservation of neural function that commands physical activities involving fine motor control. Further research appears warranted in the examination of AG ingestion and neural activity during periods of hydration stress. Acknowledgements The authors would like to thank a dedicated group of subjects. This study find more was supported by a grant from Kyowa Hakko USA, New York, NY. References 1. Nath SK, Dechelotte P, Darmaun D, Gotteland M, Rongier M, Desjeux JF: ( 15 N) and ( 14 C) glutamine fluxes across rabbit ileum

in experimental diarrhea. Am J Physiol 1992, 262:G312-G318.PubMed 2. Silva AC, Santos-Neto MS, Soares AM, Fonteles MC, Guerrant RL, Lima AA: Efficacy of a glutamine-based oral rehydration solution on the 4-Aminobutyrate aminotransferase electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. J Pediatr Gastroenterol Nutr 1998, 26:513–519.PubMedCrossRef

3. van Loon FP, Banik AK, Nath SK, Patra FC, Wahed MA, Darmaun D, Desjeux JF, Mahalanabis D: The effect of L-glutamine on salt and water absorption: a jejuna perfusion study in cholera in humans. Eur J Gastroenterol Hepatol 1996, 8:443–448.PubMed 4. Li Y, Xu B, Liu F, Tan L, Li J: The effect of glutamine-supplemented total parenteral nutrition on nutrition and intestinal absorptive function in a rat model. Pediatr Surg Int 2006, 22:508–513.PubMedCrossRef 5. Lima AA, Carvalho GH, Figueiredo AA, Gifoni AR, Soares AM, Silva EA, Guerrant RL: Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorbtion in a rat model of secretory diarrhea induced by cholera toxin. Nutr 2002, 18:458–462.CrossRef 6. Fürst P: New developments in glutamine delivery. J Nutr 2001,131(suppl):2562–2568. 7. Hoffman JR, Ratamess NA, Kang J, Rashti SL, Kelly N, Gonzalez AM, Stec M, Andersen S, Bailey BL, Yamamoto LM, Hom LL, Kupchak BR, Faigenbaum AD, Maresh CM: Examination of the efficacy of acute L-Alanyl-L-Glutamine during Hydration Stress in Endurance Exercise. J Int Soc Sports Nutr 2010, 7:8.PubMedCrossRef 8.