(1) where ϕ = arctg M y /M x are the components of the vector . In this case, a distribution of the magnetization along the axis OY has the Bloch form: sinθ = ch −1(y/Δ), where θ is the polar angle in the chosen coordinate system. It is noted that it is the area which mainly contributes to m BP = Δ/γ 2 (γ is the gyromagnetic ratio) – the effective mass of BP [19]. It is natural to assume that the abovementioned PLK inhibitor region of the DW is an actual area of

BP. Taking into account Equation 1 and assuming that the motion of BP along the DW is an automodel form ϕ = ϕ(z − z 0, x), z 0 is the coordinate of the BP’s center), we can write after a series of transformations the energy of interaction of the Bloch point W H with the external magnetic field as follows: (2) where M S is the saturation magnetization. To describe the BP dynamics caused by magnetic field H and effective field of defect H d , we will use the Lagrangian formalism. In this case, using Equation 2 and the ‘potential energy’ in the Lagrangian function , we can write it in such form (3) Expanding

H d (z 0) in series in the vicinity of the defect position, its field can be presented in the following form: BIIB057 (4) where H c is the coercive force of a defect, d is the coordinate of its center, , D is the barrier width. It is reasonable to assume that the typical change of defect field is determined by a dimensional factor of given inhomogeneity. It is clear that in our case, and hence D ~ Λ. Note also that the abovementioned point

of view about defect Anacetrapib field correlates with the results of work [20], which indicate the dependence of coercive force of a defect on the characteristic size of the DW, vertical BL, or BP. Substituting Equation 4 into Equation 3, and taking into account that in the point z 0 = 0, the ‘potential energy’ W has a local metastable minimum (see Figure 1), we obtain the following expression: (5) where (we are considering the magnetic field values H close H c , that decreases significantly the height of the potential barrier). In addition, potential W(z 0) satisfies the normalization condition where z 0,1 = 0 and are the barrier coordinates. Figure 1 Potential caused by magnetic field H and effective field of defects H d . It should be mentioned that Equation 5 corresponds to the model potential proposed in articles [13–15] for the investigation of a tunneling of DW and vertical BL through the defect. Following GPCR & G Protein inhibitor further the general concepts of the Wentzel-Kramers-Brilloin (WKB) method, we define the tunneling amplitude P of the Bloch point by the formula where and ℏ is the Planck constant.