J Bacteriol 1993,175(5):1272–1277.PubMed 5. Dulbecco CP-690550 cell line R: Production of plaques in monolayer tissue cultures by single particles of an animal virus. Proc Natl Acad Sci USA 1952,38(8):747–752.RG7112 nmr PubMedCrossRef 6. Fraenkel-Conrat H, Kimball PC: Virology. Englewood Cliffs, New Jersey: Prentice-Hall; 1982. 7. Piacitelli J, Santilli V: Relationship of tobacco mosaic virus (TMV) lesion number and concentration to the rate of lesion production on pinto bean. Nature 1961, 191:624–625.PubMedCrossRef 8. Kleczkowski A, Kleczkowski J: The ability of single phage particles to form plaques and to multiply in liquid cultures. J
Gen Microbiol 1951,5(2):346–356.PubMed 9. You L, Yin J: Amplification and spread of viruses in a growing plaque. J Theor Biol 1999, 200:365–373.PubMedCrossRef AZD1390 10. Spanakis E, Horne MT: Co-adaptation of Escherichia coli and coliphage λ vir in continuous culture. J Gen Microbiol 1987, 133:353–360.PubMed 11. Burch CL, Chao L: Evolvability of an RNA virus is determined by its mutational neighbourhood. Nature 2000,406(6796):625–628.PubMedCrossRef 12.
Abedon ST, Yin J: Bacteriophage plaques: theory and analysis. Methods Mol Biol 2009, 501:161–174.PubMedCrossRef 13. Kim WI, Kim JJ, Cha SH, Yoon KJ: Different biological characteristics of wild-type porcine reproductive and respiratory syndrome viruses and vaccine viruses and identification of the corresponding genetic determinants. J Clin Microbiol 2008,46(5):1758–1768.PubMedCrossRef 14. Sevilla N, Domingo E: Evolution of a persistent aphthovirus in cytolytic infections: partial reversion of phenotypic traits accompanied by genetic diversification. J Virol 1996,70(10):6617–6624.PubMed 15. Ruzek D, Gritsun TS, Forrester NL, Gould EA, Kopecký J, Golovchenko M, Rudenko N, Grubhoffer L: Mutations in
the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus. Virology 2008,374(2):249–255.PubMedCrossRef 16. Abedon ST, Culler RR: Bacteriophage evolution given spatial constraint. J Theor Biol 2007, 248:111–119.PubMedCrossRef 17. Gallet R, Shao Y, Wang IN: High adsorption rate is detrimental to bacteriophage Pregnenolone fitness in a biofilm-like environment. BMC Evol Biol 2009, 9:241.PubMedCrossRef 18. Abedon ST: Bacteriophages and Biofilms: Ecology, Phage Therapy, Plaques. Hauppauge, New York: Nova Science Publishers; 2011. 19. Koch AL: The growth of viral plaques during the enlargement phase. J Theor Biol 1964,6(3):413–431.PubMedCrossRef 20. Yin J, McCaskill JS: Replication of viruses in a growing plaque: a reaction-diffusion model. Biophys J 1992, 61:1540–1549.PubMedCrossRef 21. Krone SM, Abedon ST: Modeling phage plaque growth. In Bacteriophage Ecology. Edited by: Abedon ST. Cambridge, UK: Cambridge University Press; 2008. 22. Abedon ST, Culler RR: Optimizing bacteriophage plaque fecundity. J Theor Biol 2007, 249:582–592.PubMedCrossRef 23.