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Authors’ contributions VC and NK carried out the polymer and nanoparticle synthesis, polymer characterization, plasmon absorption study, and statistical analysis. MR carried out the SEC measurements and participated in the design of study and coordination. MS and CB carried out the TEM experiment. All authors read and approved the final manuscript.”
“Background Tissue engineering (TE) is the discipline which includes both creation of the new tissue and design and realization of the cells on substrates [1, 2]. Substrates TCL play a key role in creation of the cell environment [3]. To guide the organization, growth, and differentiation of cells in TE constructs, the biomaterial scaffold should be able to provide not only a physical support but also the chemical and biological clues needed in forming functional

tissue [4–6]. Biomaterials and various synthetic and natural materials, such as polymers, ceramics, metals, or their composites, have been investigated and used in different manners [5, 7]. Polymeric materials have been widely studied as substrates for tissue engineering due to their unique features such as mechanical properties, high availability, low cost, and relatively easy design and production [6, 8]. However, only a few polymers provide the biocompatibility needed to be used with the cells in vitro and in vivo[9]. High-density polyethylene (HDPE) has been extensively used for application such as the part of orthopedic implants [10]. To induce a regeneration process and to avoid the problems due to tissue replacement with a permanent implant, research has been oriented towards the development of polymers that would degrade and could be replaced by human tissue produced by the cells surrounding the material [9].