Stromata when fresh 1–6 mm diam, 0.5–1.5

mm thick, gregarious, first effuse, effluent, becoming pulvinate, compact; outline circular to oblong; margin attached or free. Surface smooth, www.selleckchem.com/products/EX-527.html without ostiolar dots, yellowish brown to light brown with white margin in early stages, later caramel to bright reddish brown, eventually dark red when mature. Stromata when dry (0.7–)1.2–5(–7) × (0.5–)1–3(–4.3) mm, 0.2–0.7(–1.1) mm thick (n = 30); first thin, membranaceous, becoming flat pulvinate when mature, broadly attached; margin mostly concolorous, partly free, rounded. Outline circular, oblong or irregularly lobed. Surface smooth, tubercular or rugose, when young finely velvety or covered by rust hairs. Ostiolar dots absent, ostiolar openings sometimes visible, (16–)20–30(–32) μm (n = 30) wide, inconspicuous, pale, more distinct and shiny after rehydration. Stromata starting as an effuse white mycelium, becoming light, yellowish-, orange-brown from the centre, 5B4, 5–6CD(E)5–8, eventually entirely medium to dark brown, 6–7E6–8, 6F7–8, 7F4–8. Rehydrated pulvinate stromata thicker than dry; hyaline ostiolar openings and radial cracks surrounding them becoming visible; turning dark red 8F6–8 to black in 3% KOH. Stroma anatomy: Ostioles (50–)56–73(–86) μm long, plane with the surface, (10–)14–24(–28) μm wide at the apex (n = 30); with convergent periphyses 1–2 μm wide, lined by a palisade of hyaline,

PD0325901 clinical trial cylindrical to subclavate cells to 3 μm wide at the apex. Perithecia (128–)145–210(–255) × (75–)115–175(–190) μm (n = 30), numerous, 7–8 per mm stroma length, subglobose or flask-shaped; peridium (9–)14–21(–25) μm (n = 60) thick at the

base and sides; hyaline to pale yellowish. Cortical layer (20–)26–43(–57) μm (n = 30) thick, a thin irregular, amorphous, pigmented crust above a dense unevenly pigmented t. angularis of indistinct, thick-walled cells (3–)4–9(–12) × (2.2–)3.5–6.0(–9.0) μm (n = 65) in face view and in vertical section; orange-brown in lactic acid, reddish brown in water. Hairs on mature stromata (7–)9–24(–40) × (2–)3–5(–6) μm (n = 35), short cylindrical, smooth, rarely verrucose, of 1 to few cells, pale brown, infrequent at the upper surface, more frequent at stroma sides. Subcortical tissue a loose hyaline t. intricata of thin-walled hyphae Interleukin-3 receptor (2–)3–5(–5.5) μm (n = 30) wide. Subperithecial tissue a hyaline t. epidermoidea of thin-walled cells (5–)8–20(–29) × (4–)6–11(–12) μm (n = 32), partly orange-brown due to basal tissue reaching upwards into the subperithecial tissue in the centre. Basal and lateral tissue towards the base a dense t. intricata of hyaline to yellowish-, or orange-brown hyphae (2.0–)2.5–5.5(–7.0) μm (n = 33) wide. Asci (69–)70–80(–84) × (3.8–)4.2–5(–5.7) μm, stipe (4–)6–12(–16) μm (n = 30) long. Ascospores hyaline, verruculose, cells dimorphic, distal cell (3.0–)3.3–3.7(–4.0) × (2.8–)3.0–3.5 μm, l/w 1.0–1.1(–1.2) (n = 34), (sub-)globose, proximal cell (3.5–)3.8–4.5(–5.0) × (2.3–)2.5–3.0 μm, l/w (1.2–)1.