Additional research needs to be conducted to further explore the potential benefits of betaine on mood. In conclusion, two-weeks of betaine supplementation in active, college males appeared to improve muscle endurance of the squat exercise, and increase the quality of repetitions performed (e.g. number of repetitions performed at 90% of 1-RM). These performance improvements were realized within 7-days of supplementation. However, no changes in power performance were seen during this study. Additional research is warranted
to determine the rate of muscle creatine synthesis Selleckchem MK0683 from betaine supplementation, and to compare muscle creatine synthesis kinetics from creatine supplementation versus betaine supplementation. Acknowledgements Study was supported by Danisco-USA, Ardsley, NY References 1. Zeisel SH, Mar MH, Howe JC, Holden JM: Concentrations of choline-containing compounds and betaine
in common foods. J Nutr 2003, 133:1302–1307.PubMed 2. Craig SAS: Betaine in human nutrition. Am J Clin Nutr 2004, 80:539–549.PubMed 3. Eklund M, Bauer E, Wamatu J, Mosenthin R: Potential nutritional and physiological functions of betaine in livestock. Nutr Res Rev 2005, 18:31–48.CrossRefPubMed 4. Olthof MR, van Vliet T, Boelsma E, Verhoef P: Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr 2003, 133:4135–4138.PubMed Selleck Ku 0059436 Casein kinase 1 5. Olthof MR, Verhoef P: Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current Drug Metab 2005, 6:15–22.CrossRef 6. Detopoulou P, Panagiotakos DB, Antonopoulou S, Pitsavos C, Stefanadis C: Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study. Am J Clin Nutr 2008, 87:424–430.PubMed 7. du Vigneaud V, Simonds S, Chandler JP, Cohn M: A further investigation of the role of betaine in transmethylation reactions in vivo. J Biol Chem 1946, 165:639–648.PubMed 8. Armstrong LE, Casa DJ, Roti MW, Lee EC, Craig SA, Sutherland JW, Fiala KA, Maresh CM: Influence of betaine consumption
on strenuous running and sprinting in a hot environment. J Strength Cond Res 2008, 22:851–60.CrossRefPubMed 9. Virtanen E: Piecing together the betaine puzzle. Feed Mix 1995, 3:12–17. 10. Fernandez-Figares I, Wray-Cahen D, Steele NC, Campbell RG, Hall DD, Virtanen E, Caperna TJ: Effect of dietary betaine on nutrient utilization and partitioning in the young growing feed-restricted pit. J Anim Sci 2002, 80:421–428.PubMed 11. Wray-Cahen D, Fernández-Fígares I, Virtanen E, Steele NC, Caperna TJ: Betaine improves growth, but does not induce whole body or hepatic palmitate oxidation in swine (Sus scrofa domestica). Comp Biochem Physiol A Mol Integr Physiol 2004, 137:131–140.CrossRefPubMed 12. Warren LK, Lawrence LM, Thompson KN: The influence of betaine on untrained and trained horses exercising to fatigue.