Increasing age and lower BMI were independent risk factors for BD in both genders. Risk factors for bone disease in cirrhosis in univariate & multivariate analysis   Univariate Multivariate OR (95%CI) P value OR (95%CI) P value Age (per 10 years) 1.67 (1.4–2.1) <0.001 1.59 (1.2–2.1) 0.001 BMI (Kg/m2) 0.93 (0.88–0.97) 0.002 0.91 (0.86–0.95) <0.001 Serum FSH (Females)

(IU/L) 1.01 (1.00–1.03) 0.04     MELD (per unit) 1.03 (0.9–1.1) 0.07     Female gender 1.43 (0.9–2.2) 0.09     Free Testosterone (Males) (nmol/L) 0.16 (0.02–1.5) 0.1   A MAJUMDAR,1 M BAILEY,2 W KEMP,1 SK ROBERTS,1 D PILCHER2,3,4 1Department of Gastroenterology, The Alfred Hospital, Melbourne, 2Australian and New Zealand Intensive Care Research Doxorubicin research buy Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3Department of Intensive Care, The Alfred Hospital, Melbourne, 4ANZICS Centre for Outcome and Resource Evaluation (CORE), Melbourne Background: There is little published population level data that describes

the outcomes of patients with cirrhosis in the intensive care unit (ICU). The aims of this study were: 1) to describe trend changes in mortality of patients with cirrhosis admitted to ICUs across Australia and New Zealand, and 2) to investigate the effect of increasing organ failures on mortality in this group. Methods: The Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database was examined. Readmissions to ICU and admissions following liver transplantation were excluded. Patients admitted to 171 ICUs with and without cirrhosis between January 1, 2000 and BTK inhibitor purchase December 31, 2011 were compared. Severity 上海皓元 of illness on admission was assessed using number of organ failures and the Acute Physiology and Chronic Health Evaluation (APACHE) III scoring system (after removal of the coefficient for cirrhosis). Results: Patients with cirrhosis accounted for 1.4% (13 379/958 853) of ICU admissions. In-hospital mortality in the cirrhotic group was 31% compared to 12% in the non-cirrhotic group (p < 0.001). Cirrhotic patients had a higher mortality rate with each

increase in number of organ failures. Cirrhotic patients with 1 organ failure had a comparable mortality to non-cirrhotic patients with 3 organ failures (20 vs 21%). In-hospital mortality decreased in both groups over time. The cirrhotic group had a 10% absolute reduction in mortality between the 2000–2003 and 2008–2011 time cohorts compared to a 3.8% reduction in the non-cirrhotic group (p < 0.001). After adjusting for baseline illness severity using logistic regression, a similar reduction in the odds ratios for mortality over time was demonstrated for both groups (Figure 1). Conclusion: The mortality of critically ill patients with cirrhosis has decreased over time. Survival in this group is better than previous reports. Mortality in cirrhosis increases with number of organ failures.