Thus, attenuation of FMD by ADMA suggests that this endogenous inhibitor of
NO synthase may, in part, mediate the vascular effects of FGF-23 in patients with CKD. Kidney International (2010) 78, 679-685; doi:10.1038/ki.2010.194; published online 7 July 2010″
“To elucidate the pathophysiologic changes in the kidney due to aging, we used physiological, morphometric, and imaging techniques to quantify GFR and its determinants in a group of 24 older (>= 55 years) compared to 33 younger (<= 45 years) living donors. Mathematical modeling was used to estimate the glomerular filtration coefficients for the whole kidney (K(f)) and for single nephrons (SNK(f)), as well Elacridar price as the number of filtering glomeruli (N(FG)). Compared to younger donors, older donors had a modest (15%) but significant depression of pre-donation GFR. Mean whole-kidney K(f), renocortical volume, Fedratinib and derived NFG were also significantly decreased in older donors. In contrast, glomerular structure and SNK(f) were not different in older and younger donors. Derived N(FG)
in the bottom quartile of older donors was less than 27% of median-derived N(FG) in the two kidneys of younger donors. Nevertheless, the remaining kidney of older donors exhibited adaptive hyperfiltration and renocortical hypertrophy post-donation, comparable to that of younger donors. Thus, our study found the decline of GFR in older donors is due to a reduction in K(f) attributable to glomerulopenia. We recommend careful monitoring for and control of post-donation comorbidities that could exacerbate glomerular loss. Kidney International (2010) 78, 686-692; doi:10.1038/ki.2010.128; published online 12 May 2010″
“BACKGROUND: Based on success with a prototype 1.5T intraoperative magnetic resonance imaging (iMRI) system and the MK-8931 desire for increased signal-to-noise ratio,
along with its relationship to image quality and advanced applications, a 3.0T system that uses the same novel moveable magnet configuration was developed.
OBJECTIVE: To assess clinical applicability by prospectively applying the higher-field system to a neurosurgical cohort.
METHODS: Upgrading to 3.0T required substantial modification of an existing iMRI-equipped operating room. The 1.5T magnet was replaced with a ceiling-mounted, moveable 3.0T magnet with a 70-cm working aperture. Local radiofrequency shielding was replaced with whole-room shielding. A new hydraulic operating table, high-performance gradients, and advanced image processing software were also installed. The new system was used as an adjunct to standard neurosurgical practice.
RESULTS: The iMRI system upgrade required 6 months. Since completion, the 3.0T iMRI system has successfully guided neurosurgery in 120 patients without system failure in a patient-focused environment. Intraoperative image quality was superior to that obtained at 1.