The superiority of liver implantation was quite obvious, especially in tumor growth environment, location and biological behavior were quite similar to human hepatoma, the proportion of the genesis of tumor metastasis, infiltration and ascites were quite high.
Therefore, the drug-resistance model established by nude mice liver implantation was capable of better simulating human hepatoma. The ideal model has similar characteristics of human heptoma biology and the pharmacokinetics of anti-cancer drugs. The utilization of this model not only allows the exploration of the molecular mechanism of hepatoma multi-drug resistance with multiple angles and targets, but also provided an ideal experiment www.selleckchem.com/products/LY2603618-IC-83.html using plates for the screening of hepatoma drug-resistant reversal agents. Acknowledgements This Project was supported by the Natural Science Foundation of Anhui Province (No, 070413069). References 1. Kessel D, Botterill V, Wodinsky I: Uptake and retention of daunomycin by mouse leukemic cells as factors in drug response. Cancer Res 1968, 28:938–941.PubMed 2. Biedler JL, Riehm H: Cellular resistance
to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies. Cancer Res 1970, 30:1174–1184.PubMed 3. Zhou XD, Tang ZY, Yang BH, Lin ZY, Ma ZC, Ye SL, Wu ZQ, Fan J, Qin LX, BAY 11-7082 in vivo Zheng BH: Experience of 1000 patients who underwent hepatectomy for small hepatocellular carcinoma. Cancer 2001, 91:1479–1486.PubMedCrossRef 4. Yang JM, Kan T, Chen H, Wu MC: Hepatectomy in the treatment of very big primary liver cancer: report of 86 cases. Hepatobiliary Pancreat Dis Int 2002, 1:42–45.PubMed 5. Pignata S, Daniele B, Gallo C, De Vivo R, Monfardini S, Perrone F: Endocrine treatment of hepatocellular carcinoma. Any evidence of benefit? Eur J Cancer 1998, 34:25–32.PubMedCrossRef PTK6 6. Urasaki Y, Ueda T, Yoshida A, Fukushima T, Takeuchi N, Tsuruo T, Nakamura T: Establishment of a daunorubicin-resistant cell line which shows multi-drug resistance by multifactorial mechanisms. Anticancer Res 1996, 16:709–714.PubMed
7. Yang LY, Trujillo JM: Biological characterization of multidrug-resistant human colon carcinoma sublines induced/selected by two methods. Cancer Res 1990, 50:3218–3225.PubMed 8. Gottesman MM, Fojo T, Bates SE: Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2002, 2:48–58.PubMedCrossRef 9. Juliano RL, Ling V: A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 1976, 455:152–162.PubMedCrossRef 10. Endo K, Maehara Y, Ichiyoshi Y, Kusumoto T, Sakaguchi Y, Ohno S, Sugimachi K: Multidrug resistance-associated protein expression in clinical gastric carcinoma. Cancer 1996, 77:1681–1687.PubMed 11. QNZ research buy Correnti M, Cavazza ME, Guedez N, Herrera O, Suarez-Chacon NR: Expression of the multidrug-resistance (MDR) gene in breast cancer. J Chemother 1995, 7:449–451.PubMed 12.