The mean scores of OHR-QoL in percentage are presented in Table 3. The participants were divided into three age groups (2–7, 8–10 and 11–15), and the percentage of means was compared. The one-sample Kolmogorov–Smirnov test revealed the skewed distribution for ECOHIS and CPQ, and hence comparison was made by Mann–Whitney test. OIDP was analysed by Independent t-test

due to its normal distribution. Statistical comparisons between total and domains of ECOHIS PI3K inhibitor and CPQ are presented in Tables 4-6. Neither the specific domains nor the items were significantly different between groups except for CPQ items 23–24 (teasing or being asked about teeth by peers in the age group of 8–10 years), wherein CBD patients were found to have a better situation (Independent t-test; P = 0.2 and P = 0.000). t = −0.73, df = 26.7 P = 0.47 t = 0.20, Palbociclib solubility dmso df = 20.09 P = 0.85 t = 1.03, df = 36 P = 0.32 t = −1.1, df = 36 P = 0.27 t = 0.385, df = 24.19 P = 0.7 NS Maintaining oral health is a priority in CBD patients. According to the results of this study, during primary dentition, young

CBD patients were more caries-free. In addition, the total number of decayed primary and permanent tooth surfaces was significantly lower in CBD. Dental situation (DMFS-DMFT scores) in 11–15-year-old CBD patients was similar to that of controls; however, when compared with a previous Iranian study [14], a much lower DMFS score is found[14]. This fact per se reflects the supportive care that CBD patients have received at young age from the CBD care centre, including exposure to topical fluoride, obligatory dental visits, regular education of patients and parents, and finally, oral reconstruction under general anaesthesia that is scheduled as a part of establishment and development of comprehensive CBD healthcare programme during the recent years [15]. It seems that older patients (11–15 years of age) may be less benefited from recent facilities. On the other hand, this finding may be attributed to MCE their adolescent period when frequent eating, more snack consumption and less parental supervision are observed. In addition, emotional distresses during this period are

blamed for salivary dysfunction and less resistance to caries [16], and their dental scores more resembled those of healthy controls. There is no consensus among the investigators with regard to dental and oral health, as well as to quality of life of CBD patients. Results similar to those of the present study have been reported in studies from England, Ireland, Germany and Egypt [17-20]; however, a poorer dental situation in CBD patients compared with controls is found in Poland, Turkey and India [20-23]. Inconsistency in the level of provided health care in different communities is probably the main causative factor. With regard to other variables including TMJ dysfunction, we could not detect more TMJ problems compared with healthy individuals.