Results: Twenty nine patients with a mean age of 10.3 ± 2.6 years were studied. Hypertension, microscopic haematuria and nephrotic-range proteinuria were seen in 66%, 86% and 60% of the patients, respectively. R788 price Forty-one per cent of biopsies showed cellular or fibrocellular crescents. Twenty patients (69%) achieved remission at the end of induction therapy. There were no significant differences in all parameters studied between responsive and nonresponsive groups.
The relapse rate after maintenance therapy was 58.8%. Conclusion: Our results show that pulse cyclophosphamide is an effective regimen for induction therapy in children with diffuse
proliferative glomerulonephritis. No definite predictor for unresponsiveness was detected in this study. “
“Aim: Although recent genetic studies suggested that several genetic variants increase the risk for chronic kidney disease (CKD), the genes that underlie genetic susceptibility to this condition remain to be identified definitively. We showed that the CT polymorphism see more (rs6929846) of BTN2A1 and AG polymorphism (rs2569512) of ILF3 were significantly associated with myocardial infarction in Japanese individuals by a genome-wide association study. The purpose of the present study was to examine a possible PIK3C2G association of these polymorphisms (rs6929846, rs2569512) with CKD in Japanese individuals. Methods: A total of 7542 Japanese individuals from two independent populations were examined: Subject panel A comprised 971 individuals with CKD (estimated glomerular filtration rate (eGFR) <60 mL/min 1.73 m−2)) and 2269 controls (eGFR ≥60 mL/min
1.73 m−2); and subject panel B comprised 1318 individuals with CKD and 2984 controls. Results: The χ2 test revealed that rs6929846 of BTN2A1, but not rs2569512 of ILF3, was significantly related to the prevalence of CKD both in subject panels A (P = 0.0383) and B (P = 0.0477). Multivariable logistic regression analysis with adjustment for covariates revealed that the CT polymorphism (rs6929846) of BTN2A1 was significantly associated with the prevalence of CKD in subject panels A (P = 0.0422; recessive model; odds ratio, 2.36) and B (P = 0.0386; dominant model; odds ratio, 1.21) with the T allele representing a risk for this condition. Conclusion: Our results suggest that BTN2A1 may be a susceptibility gene for CKD in Japanese individuals.