Oncol Rep 2011, 26:593–601.PubMed 24. Pan Y, Jiao J, Zhou C, Cheng Q, Hu Y, Chen H: Nanog is highly expressed in ovarian serous cystadenocarcinoma and correlated with clinical stage and pathological grade. Pathobiology 2010, 77:283–288.PubMedCrossRef 25. Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Konishi J, Oizumi S, et al.: Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance. Cancer 4SC-202 purchase 2010, 116:3015–3024.PubMedCrossRef 26. Woo T, Okudela K, Mitsui H, Yazawa T, Ogawa N, Tajiri M, et
al.: Prognostic value of CD133 expression in stage I lung adenocarcinomas. Int J Clin Exp Pathol 2010, 4:32–42.PubMed 27. Sholl LM, Long KB, Hornick JL: Sox2 Expression in pulmonary non-small cell and neuroendocrine carcinomas. Appl Immunohistochem Mol Morphol 2010, 18:55–61.PubMedCrossRef 28. Lu Y, Futtner C, Rock JR, Xu X, Whitworth W, Hogan BL, et al.: Evidence that SOX2 overexpression is oncogenic APR-246 datasheet in the lung. PLoS One 2010, 5:e11022.PubMedCrossRef 29. Chiou SH, Wang ML, Chou YT, Chen CJ, Hong CF, Hsieh WJ, et al.: Coexpression of oct4 and nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. Cancer Res 2010, 70:10433–10444.PubMedCrossRef
30. Cantz T, Key G, Bleidissel M, Gentile L, Han DW, Brenne A, et al.: Absence of OCT4 expression in somatic tumor cell lines. Stem Cells 2008, 26:692–697.PubMedCrossRef 31. Vrzalikova K, Skarda J, Ehrmann J, Murray PG, Fridman E, Kopolovic J, ID-8 et al.: Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study. J Cancer
Res Clin Oncol 2008, 134:1037–1042.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions LDL and HNY collected data and specimens, carried out the RT-PCR and immunochemistry staining, analyzed the results and drafted the manuscript. XYW conceived and designed the experiments, drafted and revised the manuscript critically and gave final approval of the version to be published. JRZ and DYL helped to collected bronchoscopic biopsy specimens. JYL helped to carry out the immunochemistry staining and assessed the slides. CMW, JYW, JHW and MJ participated in study coordination and statistical analysis. BWM conceived and designed of the study, performed the interpretation of data, literature search, writing and revising. All authors read and approved the final manuscript.”
“Background Medulloblastoma (MB) is the most GSK2126458 order common malignant brain tumor in childhood and accounts for 20% of such entities. It arises during embryonic development from neural precursor cells in the precerebellum or the dorsal brain stem [1].