N Engl J Med 354:821–831PubMedCrossRef 12. Miller PD, Bolognese MA, Lewiecki EM, McClung MR, Ding B, Austin M, Liu Y, San Martin J, Amg Bone Loss Study G (2008) Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of BIBF 1120 order therapy: a randomized blinded phase 2 clinical trial. Bone 43:222–229PubMedCrossRef 13. Miller PD, Wagman RB, Peacock

M, Lewiecki EM, Bolognese MA, Weinstein RL, Ding B, San Martin J, McClung MR (2011) Effect of denosumab on bone mineral density and biochemical markers of bone turnover: six-year results of a phase 2 clinical trial. J check details Clin Endocrinol Metab 96:394–402PubMedCrossRef 14. Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C (2009) Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361:756–765PubMedCrossRef 15. Bone HG, Hosking D, Devogelaer JP, Tucci JR, Emkey MLN8237 in vivo RD, Tonino RP, Rodriguez-Portales JA, Downs RW, Gupta J, Santora

AC, Liberman UA (2004) Ten years’ experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med 350:1189–1199PubMedCrossRef 16. Mellstrom DD, Sorensen OH, Goemaere S, Roux C, Johnson TD, Chines AA (2004) Seven years of treatment with risedronate in women with postmenopausal osteoporosis. Calcif Orotic acid Tissue Int 75:462–468PubMedCrossRef 17. Papapoulos S, Chapurlat R, Libanati C, Brandi M, Brown J, Czerwinski E, Krieg MA, Man Z, Mellstrom D, Radominski S, Reginster JY, Resch

H, Roman J, Roux C, Vittinghoff E, Austin M, Daizadeh N, Bradley M, Grauer A, Cummings S, Bone H (2011) Five years of denosumab exposure in women with postmenopausal osteoporosis: results from the first two years of the FREEDOM extension. J Bone Miner Res 27:694–701 18. Brown JP, Prince RL, Deal C, Recker RR, Kiel DP, de Gregorio LH, Hadji P, Hofbauer LC, Alvaro-Gracia JM, Wang H, Austin M, Wagman RB, Newmark R, Libanati C, San Martin J, Bone HG (2009) Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial. J Bone Miner Res 24:153–161PubMedCrossRef 19. Genant HK, Engelke K, Hanley DA, Brown JP, Omizo M, Bone HG, Kivitz AJ, Fuerst T, Wang H, Austin M, Libanati C (2010) Denosumab improves density and strength parameters as measured by QCT of the radius in postmenopausal women with low bone mineral density. Bone 47:131–139PubMedCrossRef 20.