A three part questionnaire was developed and administered to collect: (1) demographic information; (2) level of medication awareness; (3) self-reported medication errors; and (4) perception of benefit of a medication card.
The responses were scored to assess medication understanding and perception of a medication card. The data was analysed with SPSS v.22 and P < 0.05 considered significant. Results: 26 out of 34 patients completed the questionnaire with 57% being male and the average age 61.3 (± 11.3) years. Patients took 7.9 (± 3) medications, BAY 73-4506 manufacturer 73.1% of respondents had high school or less education and 38% reported English as their primary language. There was no association between medical comorbidities, level of education or primary language with medication awareness. Women demonstrated better medication awareness than males (58 ± 5 vs 42 ± 5, P < 0.05). There was increasing acceptance of the benefits of a medication card as education level improved (P < 0.05). 15% of patients report an adverse drug reaction in the previous year. Conclusions: There is acceptance for the use of medication cards by HD patients who are subject to polypharmacy and this may improve medication awareness. Women appear to have better medication awareness. 204
INVERSE ASSOCIATION BETWEEN 25-HYDROXY-VITAMIN D CONCENTRATIONS AND SERUM LEVELS OF PRO-ATHEROGENIC CYTOKINES IN CHRONIC Lumacaftor order Calpain KIDNEY DISEASE PATIENTS E ROUSE1,2, K YOUNG 1,2, WH LIM1,2 1Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, WA; 2School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia Aim: To determine the association between novel risk factors for cardiovascular disease (CVD) and circulating pro-atherogenic cytokines and arterial stiffness in chronic kidney disease (CKD) patients. Background: Novel risk factors for CVD including oxidised
low-density lipoprotein (oxLDL) and vitamin D have been implicated in the pathogenesis of CVD in CKD patients. High levels of circulating oxLDL level and 25-hydroxy-vitamin D (25OHD) deficiency are associated with inflammation, increased pulse wave velocity and CVD mortality in the general population and early CKD patients but a similar association has not been consistently shown in pre-dialysis advanced CKD patients. Methods: This was a cross-sectional study of 40 pre-dialysis stage 5 CKD patients recruited from a single-centre. Plasma oxLDL levels (ELISA), 25OHD concentration, interleukin (IL)-12 and 18 (ELISA) and pulse wave velocity (PWV, SphygmoCor® system) were determined at a single time-point. Associations between log-transformed oxLDL (log-oxLDL) and log-25OHD with IL-12/18 and PWV were examined using linear regression analysis. Results: Mean ± SD age was 65 ± 13 years with 72% of male gender.